catalog number :
MBS1265305
products type :
Recombinant Protein
products full name :
Recombinant human Alpha-enolase
products short name :
Alpha-enolase
sequence :
SILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGAS
TGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVS
KKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAV
CKAGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGS
HAGNKLAMQEFMILPVGAANFREAMRIGAEVYHNLKNVI
KEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAG
YTDKVVIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPD
QLADLYKSFIKDYPVVSIEDPFDQDDWGAWQKFTASAGI
QVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTE
SLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLCTG
QIKTGAPCRSERLAKYNQLLRIEEELGSKAKFAGRNF
storage stability :
Store at -20 degree C. For extended storage, conserve at -20 or -80 degree C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
products description :
Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.
uniprot summary :
ENO1: an abundant cytoplasmic enzyme with 2-phospho-D-glycerate hydro-lyase activity. A target of excess protein nitration in Alzheimer disease (AD) brain. Tau-crystallin, a structural lens protein, is produced from an alternative translation start in the enolase gene. Protein type: Transcription, coactivator/corepressor; EC 4.2.1.11; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Lyase. Chromosomal Location of Human Ortholog: 1p36.2. Cellular Component: extracellular space; phosphopyruvate hydratase complex; membrane; cytoplasm; plasma membrane; M band; nucleus; cytosol. Molecular Function: protein binding; DNA binding; magnesium ion binding; phosphopyruvate hydratase activity; transcription factor activity; transcription corepressor activity. Biological Process: glycolysis; transcription, DNA-dependent; response to virus; carbohydrate metabolic process; glucose metabolic process; pathogenesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; gluconeogenesis