catalog number :
MBS1265230
products type :
Recombinant Protein
products full name :
Recombinant human Bone morphogenetic protein 2
products short name :
Bone morphogenetic protein 2
other names :
bone morphogenetic protein 2 preproprotein; Bone morphogenetic protein 2; bone morphogenetic protein 2; BMP-2A; bone morphogenetic protein 2A; bone morphogenetic protein 2; Bone morphogenetic protein 2A
other gene names :
BMP2; BMP2; BDA2; BMP2A; BMP2A; BMP-2; BMP-2A
uniprot entry name :
BMP2_HUMAN
sequence :
QAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYH
AFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKAC
CVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
storage stability :
Store at -20 degree C. For extended storage, conserve at -20 or -80 degree C.
other info1 :
Tag Information: Host tag may vary. Please inquire for specific tag information.
ncbi acc num :
NP_001191.1
ncbi gb acc num :
NM_001200.2
ncbi mol weight :
44,702 Da
ncbi pathways :
Adipogenesis Pathway 198832!!BDNF Signaling Pathway 712093!!BMP Signalling And Regulation Pathway 198910!!Basal Cell Carcinoma Pathway 83113!!Basal Cell Carcinoma Pathway 525!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Elastic Fibre Formation Pathway 730310!!Extracellular Matrix Organization Pathway 576262!!Heart Development Pathway 198802
ncbi summary :
The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: Induces cartilage and bone formation. Subunit structure: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN . By similarity. Ref.4. Subcellular location: Secreted. Tissue specificity: Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine. Pharmaceutical use: Available under the name Infuse (Medtronic Sofamor Danek). Used for treating open tibial shaft fractures. Sequence similarities: Belongs to the TGF-beta family.