catalog number :
MBS1265096
products type :
Recombinant Protein
products full name :
Recombinant human Antigen KI-67, partial
products short name :
Antigen KI-67
other names :
antigen KI-67 isoform 2; Antigen KI-67; antigen KI-67; proliferation-related Ki-67 antigen; antigen identified by monoclonal antibody Ki-67
other gene names :
MKI67; MKI67; KIA; MIB-1
uniprot entry name :
KI67_HUMAN
sequence positions :
3120-3256aa; Fragment at the C-terminal.
sequence :
NQKGKGEAGNSDSMCLRSRKTKSQPAASTLESKSVQRVTRSVKRCAENPKKAEDNVCVKKIRTRS HRDSEDI
NEKKPMKTSPEMDIQNPDDGARKPIPRDKVTENKRCLRS
ARQNESSQPKVAEESGGQKSAKVLMQ
storage stability :
Store at -20 degree C. For extended storage, conserve at -20 or -80 degree C.Notes ? Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
products description :
Thought to be required for maintaining cell proliferation.
ncbi acc num :
NP_001139438.1
ncbi gb acc num :
NM_001145966.1
ncbi summary :
This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]
uniprot summary :
KI-67: a protein that may be a marker of proliferating cells, involved in chromatin compaction. Its expression is altered in many tumor types including osteosarcomas, histiocytomas, prostate, breast and esophageal cancers. Mutated in colon, cervical and lung cancers. Protein type: Nucleolus; Cell cycle regulation. Chromosomal Location of Human Ortholog: 10q26.2. Cellular Component: membrane; cytoplasm; nucleolus; condensed chromosome; nucleus; chromosome, pericentric region. Molecular Function: protein C-terminus binding; protein binding; ATP binding. Biological Process: meiosis; cell proliferation