GNA15 Polyclonal Antibody | MyBioSource MBS126354 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

GNA15 Polyclonal Antibody

catalog :

MBS126354

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of mouse heart, using GNA15 antibody. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.

image 2 :

Immunohistochemistry of paraffin-embedded human tonsil using GNA15 antibody at dilution of 1:100 (40x lens).

image 3 :

Immunohistochemistry of paraffin-embedded human breast cancer using GNA15 antibody at dilution of 1:100 (40x lens).

product information

catalog number :

MBS126354

products type :

Antibody

products full name :

GNA15 Polyclonal Antibody

products short name :

[GNA15]

products name syn :

[GNA16]

other names :

[Guanine nucleotide-binding protein subunit alpha-15; Guanine nucleotide-binding protein subunit alpha-15; guanine nucleotide-binding protein subunit alpha-15; g alpha-15; g alpha-16; G-protein subunit alpha-15; G-protein subunit alpha-16; epididymis tissue protein Li 17E; guanine nucleotide-binding protein subunit alpha-16; guanine nucleotide binding protein (G protein), alpha 15 (Gq class); Epididymis tissue protein Li 17E; Guanine nucleotide-binding protein subunit alpha-16; G alpha-16; G-protein subunit alpha-16]

products gene name :

[GNA15]

other gene names :

[GNA15; GNA15; GNA16; GNA16; G alpha-15; G-protein subunit alpha-15; G alpha-16; G-protein subunit alpha-16]

uniprot entry name :

GNA15_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

374

purity :

Affinity Purification

concentration :

1mg/ml

storage stability :

Store at -20 degree C. Avoid freeze / thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500 - 1:2000. IHC: 1:50 - 1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Species: Human. Category: Primary antibody

other info2 :

Immunogen: Recombinant protein of human GNA15. Calculated Molecular Weight: 44kDa. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

products categories :

Polyclonal

products description :

Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors (1). Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (i.e., adenylyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein ¥, ˆ« and © polypeptides are encoded by at least 16, 4 and 7 genes, respectively (2-5). Most interest in G proteins has been focused on their a subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four distinct classes of G¥ subunits have been identified; these include Gs, Gi, Gq and Ga 12/13 (3,4). The Gi class comprises all the known a subunits that are susceptible to pertussis toxin modifications, including Ga i-1, Ga i-2, Ga i-3, Ga o, Ga t1, Ga t2, Ga z and Ga gust (4). Of these, the three Ga i subtypes function to open atrial potassium channels (6). Ga 16 is a member of the Gq subfamily and is expressed specifically in hematopoietic cells (7).

ncbi gi num :

311033388

ncbi acc num :

P30679.2

uniprot acc num :

P30679

ncbi pathways :

ADP Signalling Through P2Y Purinoceptor 1 Pathway (161061); Acetylcholine Regulates Insulin Secretion Pathway (105924); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Arf6 Signaling Events Pathway (138034); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Endothelin Pathway (672453)

uniprot summary :

G-alpha 15: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Belongs to the G-alpha family. G(q) subfamily. Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q). Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: plasma membrane; heterotrimeric G-protein complex. Molecular Function: GTPase activity; signal transducer activity; G-protein-coupled receptor binding; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding. Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; platelet activation; elevation of cytosolic calcium ion concentration; phospholipase C activation; metabolic process; dopamine receptor, phospholipase C activating pathway; blood coagulation; muscarinic acetylcholine receptor, phospholipase C activating pathway

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

275

size3 :

0.2 mL

price3 :

430

more info or order :

MyBioSource product webpage