Histone H4R3me2a Polyclonal Antibody | MyBioSource MBS126223 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Histone H4R3me2a Polyclonal Antibody

catalog :

MBS126223

quantity :

0.05 mL

price :

265 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS126223

products type :

Antibody

products full name :

Histone H4R3me2a Polyclonal Antibody

products short name :

H4R3me2a

products name syn :

Asymmetric DiMethyl-Histone H4-R3: H3t; H3.4; H3/g; H3FT

other names :

Histone H4; Histone H4; histone H4; histone 2, H4a; H4 histone, family 2; histone IV, family 2; H4 histone family, member N; histone cluster 2, H4a

products gene name :

H4R3me2a

other gene names :

HIST2H4A; HIST1H4A; H4; H4/n; H4F2; H4FN; FO108; HIST2H4; H4/A; H4FA

uniprot entry name :

H4_HUMAN

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat, Other (Wide Range)

sequence length :

103

purity :

Affinity Purification

concentration :

1mg/ml

storage stability :

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

app notes :

WB: 1:500 - 1:2000. IHC: 1:50 - 1:200. IF: 1:50 - 1:200. IP: 1:50 - 1:100

other info1 :

Species: Human. Route: Synthetic Peptide

other info2 :

Immunogen: A synthetic methylated peptide corresponding to residues surrounding Arg3 of human histone H4. Calculated Molecular Weight: 11kDa

products categories :

Methylation

products description :

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element.

ncbi gi num :

51317339

ncbi acc num :

P62805.2

uniprot acc num :

P62805

ncbi pathways :

Alcoholism Pathway (585563); Alcoholism Pathway (587116); Amyloids Pathway (366238); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Cellular Senescence Pathway (905991); Cellular Responses To Stress Pathway (645258); Chromatin Modifying Enzymes Pathway (1127682); Chromatin Organization Pathway (1127681); Chromosome Maintenance Pathway (161048)

ncbi summary :

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Jul 2008]

uniprot summary :

H4: histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The gene encoding H4 is intronless. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 6p22.2. Cellular Component: nucleoplasm; nuclear chromosome; protein complex; membrane; extracellular region; nucleosome; nucleus. Molecular Function: protein binding; DNA binding; histone binding; protein heterodimerization activity. Biological Process: chromatin silencing at rDNA; nucleosome assembly; establishment and/or maintenance of chromatin architecture; DNA replication-independent nucleosome assembly at centromere; DNA replication-independent nucleosome assembly; negative regulation of gene expression, epigenetic; protein heterotetramerization; gene expression; mitotic cell cycle; DNA methylation on cytosine; regulation of gene expression, epigenetic; DNA replication-dependent nucleosome assembly; telomere maintenance; negative regulation of megakaryocyte differentiation

size1 :

0.05 mL

price1 :

265 USD

size2 :

0.1 mL

price2 :

380

size3 :

0.2 mL

price3 :

555

more info or order :

MyBioSource product webpage