catalog number :
MBS126105
products full name :
VCAM1 Polyclonal Antibody
products short name :
VCAM1
products name syn :
VCAM1; L1CAM; VCAM 1; V CAM 1; DKFZp779G2333; CD106
other names :
Vascular cell adhesion protein 1; Vascular cell adhesion protein 1; vascular cell adhesion protein 1; CD106 antigen; vascular cell adhesion molecule 1; INCAM-100; CD_antigen: CD106
products gene name :
VCAM1
other gene names :
VCAM1; VCAM1; CD106; INCAM-100; L1CAM; V-CAM 1; VCAM-1
uniprot entry name :
VCAM1_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Affinity Purification
storage stability :
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500 - 1:2000. IHC: 1:50 - 1:200
other info1 :
Species: Human. Route: Recombinant Protein
other info2 :
Immunogen: Recombinant Protein of human VCAM1. Calculated Molecular Weight: 81kDa
products categories :
Polyclonal
products description :
Vascular cell adhesion protein 1 (VCAM1) is important in cell-cell recognition. It has been reported to function in leukocyte-endothelial cell adhesion, interact with the beta-1 integrin VLA4 on leukocytes, and mediate both adhesion and signal transduction. There are two isoforms; Isoform 1, a single-pass type I membrane protein, and isoform 2, a lipid-anchor (GPI-anchor). VCAM1 is expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. It is also expressed in the bone marrow (1).
ncbi pathways :
Adaptive Immune System Pathway 366160!!African Trypanosomiasis Pathway 194384!!African Trypanosomiasis Pathway 194323!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480!!Cellular Roles Of Anthrax Toxin Pathway 138076!!Cytokine Signaling In Immune System Pathway 366171!!Extracellular Matrix Organization Pathway 576262!!HTLV-I Infection Pathway 373901!!HTLV-I Infection Pathway 373889
ncbi summary :
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]