catalog number :
MBS125844
products full name :
PPARG Polyclonal Antibody
products short name :
PPARG
products name syn :
PPARgamma: PPARg; PPARG; PPAR gamma; CIMT1; PPARG2; PPARG1; NR1C3
other names :
Peroxisome proliferator-activated receptor gamma; Peroxisome proliferator-activated receptor gamma; peroxisome proliferator-activated receptor gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated nuclear receptor gamma variant 1; peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3
products gene name :
PPARG
other gene names :
PPARG; PPARG; GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma; NR1C3; PPAR-gamma
uniprot entry name :
PPARG_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Affinity Purification
storage stability :
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
WB: 1:500 - 1:1000. IHC: 1:50 - 1:100. IF: 1:50 - 1:100
other info1 :
Species: Human. Route: Synthetic Peptide
other info2 :
Immunogen: N term -peptide of human PPARG. Calculated Molecular Weight: 58kDa
products categories :
Polyclonal
products description :
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the ligand-activated nuclear receptor superfamily and functions as a transcriptional activator (1). PPARgamma is preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage (2). Besides its role in mediating adipogenesis and lipid metabolism (2), PPARgamma also modulates insulin sensitivity, cell proliferation and inflammation (3). PPARgamma transcriptional activity is inhibited by MAP kinase phosphorylation of PPARgamma at Ser84 (4,5).
ncbi pathways :
AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Adipogenesis Pathway 198832!!Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway 137993!!Developmental Biology Pathway 477129!!Energy Metabolism Pathway 198907!!Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway 160977!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!Huntington's Disease Pathway 83100
ncbi summary :
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]