antibody

ATF4 Polyclonal Antibody

MBS125836

0.05 mg

230 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry

Antibody

ATF4 Polyclonal Antibody

ATF4

ATF4; CREB-2; CREB2; TAXREB67; TXREB

Cyclic AMP-dependent transcription factor ATF-4; Cyclic AMP-dependent transcription factor ATF-4; cyclic AMP-dependent transcription factor ATF-4; DNA-binding protein TAXREB67; tax-responsive enhancer element B67; cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; cyclic AMP-responsive element-binding protein 2; tax-responsive enhancer element-binding protein 67; activating transcription factor 4; Activating transcription factor 4; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; Tax-responsive enhancer element-binding protein 67; TaxREB67

ATF4

ATF4; ATF4; CREB2; TXREB; CREB-2; TAXREB67; CREB2; TXREB; cAMP-dependent transcription factor ATF-4; CREB-2; cAMP-responsive element-binding protein 2; TaxREB67

ATF4_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

351

Affinity Purification

1mg/ml

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:500 - 1:2000. IHC: 1:50 - 1:200

Species: Human. Route: Recombinant Protein

Immunogen: Recombinant protein of human ATF4. Calculated Molecular Weight: 39kDa

Polyclonal

ATF4 is a transcription factor, that accumulates predominantly in osteoblasts, where it regulates terminal osteoblast differentiation and bone formation. As a basic leucine-zipper (bZip) transcription factor, ATF4 can regulate amino acid metabolism, cellular redox state, and anti-stress responses. It also regulates age-related and diet-induced obesity and glucose homeostasis in mammals, and has conserved metabolic functions in flies. Due to its location at chromosome 22q13, a region linked to schizophrenia, ATF4 is considered as a positional candidate gene for schizophrenia. Otherwise, since ATF4 is induced by tumour microenvironmental factors, and regulates processes relevant to cancer progression, it might serve as a potential therapeutic target in cancer. This antibody is a rabbit polyclonal antibody raised against full length human ATF4 antigen.

116241262

P18848.3

P18848

351

ATF4 Activates Genes Pathway 530772!!ATF6-alpha Activates Chaperone Genes Pathway 530770!!ATF6-alpha Activates Chaperones Pathway 105905!!Adrenergic Signaling In Cardiomyocytes Pathway 908257!!Adrenergic Signaling In Cardiomyocytes Pathway 909696!!Alcoholism Pathway 585563!!Alcoholism Pathway 587116!!Amphetamine Addiction Pathway 547607!!Amphetamine Addiction Pathway 550546!!Cholinergic Synapse Pathway 217716

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

0.05 mg

230 USD