catalog number :
MBS1256725
products type :
Recombinant Protein
products full name :
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) Lanosterol 14-alpha demethylase
products short name :
Lanosterol 14-alpha demethylase
products name syn :
CYPLI; Cytochrome P450 51; Cytochrome P450-14DM; Cytochrome P450-LIA1; Sterol 14-alpha demethylase
other names :
sterol 14-demethylase; Lanosterol 14-alpha demethylase; sterol 14-demethylase; CYPLI; Cytochrome P450 51; Cytochrome P450-14DM; Cytochrome P450-LIA1; Sterol 14-alpha demethylase
products gene name :
ERG11
other gene names :
ERG11; ERG11; CYP51; CYP51
uniprot entry name :
CP51_YEAST
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
20-Jan
sequence :
MSATKSIVGEALEYVNIGLS
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info2 :
Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
products description :
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
products references :
Primary structure of the P450 lanosterol demethylase gene from Saccharomyces cerevisiae."
Kalb V.F., Woods C.W., Turi T.G., Dey C.R., Sutter T.R., Loper J.C.
DNA 6:529-537(1987)
ncbi acc num :
NP_011871.1
ncbi gb acc num :
NM_001179137.1
ncbi mol weight :
60,720 Da
ncbi pathways :
Biological Oxidations Pathway (1334359); Biosynthesis Of Antibiotics Pathway (1146303); Biosynthesis Of Secondary Metabolites Pathway (148673); Cholesterol Biosynthesis Pathway (198747); Cholesterol Biosynthesis Pathway (1334229); Cytochrome P450 - Arranged By Substrate Type Pathway (1334361); Endogenous Sterols Pathway (1334362); Ergosterol Biosynthesis Pathway (198728); Metabolic Pathways (131993); Metabolism Pathway (1334173)