product summary
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company name :
MyBioSource
product type :
antibody
product name :
cPLA2 Polyclonal Antibody
catalog :
MBS125633
quantity :
0.1 mg
price :
305 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, FACS
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS125633
products type :
Antibody
products full name :
cPLA2 Polyclonal Antibody
products short name :
cPLA2
products name syn :
Cytosolic phospholipase A2; cPLA2; Phospholipase A2 group IVA; Lysophospholipase; PLA2G4; CPLA2; PLA2G4A
other names :
Cytosolic phospholipase A2; Cytosolic phospholipase A2; cytosolic phospholipase A2; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein; phospholipase A2, group IVA (cytosolic, calcium-dependent); Phospholipase A2 group IVAIncluding the following 2 domains:Phospholipase A2 (EC:3.1.1.4)Alternative name(s):Phosphatidylcholine 2-acylhydrolase
products gene name :
PLA2G4A
other gene names :
PLA2G4A; PLA2G4A; PLA2G4; cPLA2-alpha; CPLA2; PLA2G4; cPLA2
uniprot entry name :
PA24A_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human
sequence length :
749
purity :
Affinity Purification
concentration :
1mg/ml
storage stability :
Store at 4 degree C (regular) or -20 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS)
app notes :
WB: 1:200 - 1:500. IHC: 1:50 - 1:100. IF: 1:20 - 1:50. FC: 1:20 - 1:50
other info1 :
Species: Human. Route: Synthetic Peptide
other info2 :
Immunogen: A synthetic peptide of human cPLA2. Calculated Molecular Weight: 85kDa
products categories :
Polyclonal
products description :
Cytosolic phospholipase A2 (cPLA2) is a ubiquitously distributed enzyme that catalyzes the hydrolysis of the sn-2 acyl bond of glycerolipids to produce lysophospholipids and release arachidonic acid (1). cPLA2 has been implicated in diverse cellular responses such as mitogenesis, differentiation, inflammation and cytotoxicity (1). Calcium binding to the amino-terminal CalB domain of cPLA2 promotes the translocation of cPLA2 from cytosol to membrane, where cPLA2 cleaves arachidonic acid from natural membrane (2). Phosphorylation of cPLA2 by MAPK (p42/44 and p38) at Ser505 (3,4) and Ser727 (5) stimulates its catalytic activity.
ncbi gi num :
317373312
ncbi acc num :
P47712.2
uniprot acc num :
P47712
ncbi mol weight :
749
ncbi pathways :
ADP Signalling Through P2Y Purinoceptor 1 Pathway 161061!!AGE/RAGE Pathway 698754!!Acyl Chain Remodeling Of CL Pathway 645330!!Acyl Chain Remodelling Of PC Pathway 645321!!Acyl Chain Remodelling Of PE Pathway 645317!!Acyl Chain Remodelling Of PG Pathway 645328!!Acyl Chain Remodelling Of PI Pathway 645326!!Acyl Chain Remodelling Of PS Pathway 645324!!Arachidonic Acid Metabolism Pathway 82991!!Arachidonic Acid Metabolism Pathway 685553
ncbi summary :
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008]
size :
0.1 mg
price :
305 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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