product summary
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company name :
MyBioSource
product type :
antibody
product name :
DOK4 Polyclonal Antibody
catalog :
MBS125627
quantity :
0.05 mL
price :
230 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS125627
products type :
Antibody
products full name :
DOK4 Polyclonal Antibody
products short name :
DOK4
products name syn :
DOK4; docking protein 4; FLJ10488; Insulin receptor substrate 5; IRS5; IRS 5
other names :
Docking protein 4; Docking protein 4; docking protein 4; IRS5; IRS-5; insulin receptor substrate 5; downstream of tyrosine kinase 4; docking protein 4; Downstream of tyrosine kinase 4; Insulin receptor substrate 5; IRS-5; IRS5
products gene name :
DOK4
other gene names :
DOK4; DOK4; IRS-5; IRS5
uniprot entry name :
DOK4_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
326
purity :
Affinity Purification
concentration :
1mg/ml
storage stability :
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
WB: 1:500 - 1:2000. IHC: 1:50 - 1:200. IF: 1:50 - 1:200
other info1 :
Species: Human. Immunogen: Recombinant Protein
other info2 :
Immunogen: Recombinant Protein of human DOK4. Calculated Molecular Weight: 37kDa
products categories :
Polyclonal
products description :
The downstream of kinase family (Dok-1-7) are members of a class of docking proteins that interact with receptor tyrosine kinases and, via this interaction, mediate biological responses within the body. Dok-4 (Downstream of kinase-4) is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.
ncbi gi num :
84029600
ncbi acc num :
Q8TEW6.2
uniprot acc num :
Q8TEW6
ncbi mol weight :
326
ncbi pathways :
Signaling Events Regulated By Ret Tyrosine Kinase Pathway (137915)
uniprot summary :
DOK4: docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in Ret-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of Ret in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. Interacts with Ret and TIE2. Interaction with Ret is mediated through the PTB domain and requires phosphorylation of Ret Y1062. Protein type: Adaptor/scaffold; Cell development/differentiation. Chromosomal Location of Human Ortholog: 16q21. Molecular Function: protein binding; receptor signaling protein activity; insulin receptor binding. Biological Process: nervous system development; MAPKKK cascade; transmembrane receptor protein tyrosine kinase signaling pathway
size1 :
0.05 mL
price1 :
230 USD
size2 :
0.1 mL
price2 :
305
size3 :
0.2 mL
price3 :
460
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

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