antibody

GRIA2 Polyclonal Antibody

MBS125520

0.05 mg

285 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry

Antibody

GRIA2 Polyclonal Antibody

GRIA2

AMPA Receptor: GLUR2; GLURB; GluA2; HBGR2; GluR-K2

Glutamate receptor 2; Glutamate receptor 2; glutamate receptor 2; gluR-2; gluR-B; AMPA-selective glutamate receptor 2; glutamate receptor, ionotropic, AMPA 2; AMPA-selective glutamate receptor 2; GluR-B; GluR-K2; Glutamate receptor ionotropic, AMPA 2; GluA2

GRIA2

GRIA2; GRIA2; GLUR2; GLURB; GluA2; HBGR2; GluR-K2; GLUR2; GluR-2; GluA2

GRIA2_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

883

Affinity Purification

1mg/ml

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:500 - 1:2000

Species: Human. Route: Recombinant Protein

Immunogen: Recombinant protein of human GRIA2. Calculated Molecular Weight: 99kDa

Polyclonal

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.

23831146

P42262.3

P42262

883

Activation Of AMPA Receptors Pathway 106539!!Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway 161033!!Amphetamine Addiction Pathway 547607!!Amphetamine Addiction Pathway 550546!!Amyotrophic Lateral Sclerosis (ALS) Pathway 83099!!Amyotrophic Lateral Sclerosis (ALS) Pathway 511!!BDNF Signaling Pathway 712093!!Circadian Entrainment Pathway 698773!!Circadian Entrainment Pathway 699872!!Cocaine Addiction Pathway 546258

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG- Q- R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]

0.05 mg

285 USD