NCOA1 Polyclonal Antibody | MyBioSource MBS125472 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

NCOA1 Polyclonal Antibody

catalog :

MBS125472

quantity :

0.05 mL

price :

285 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS125472

products type :

Antibody

products full name :

NCOA1 Polyclonal Antibody

products short name :

NCOA1

products name syn :

SRC-1: F-SRC-1; KAT13A; MGC129719; MGC129720; NCoA-1; RIP160; SRC-1; SRC1; bHLHe42; bHLHe74

other names :

Nuclear receptor coactivator 1; Nuclear receptor coactivator 1; nuclear receptor coactivator 1; Hin-2 protein; PAX3/NCOA1 fusion protein; steroid receptor coactivator-1; renal carcinoma antigen NY-REN-52; class E basic helix-loop-helix protein 74; nuclear receptor coactivator 1; Class E basic helix-loop-helix protein 74; bHLHe74; Protein Hin-2; RIP160; Renal carcinoma antigen NY-REN-52; Steroid receptor coactivator 1; SRC-1

products gene name :

NCOA1

other gene names :

NCOA1; NCOA1; SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74; BHLHE74; SRC1; NCoA-1; bHLHe74; SRC-1

uniprot entry name :

NCOA1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

1441

purity :

Affinity Purification

concentration :

1mg/ml

storage stability :

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500 - 1:1000. IHC: 1:50 - 1:100

other info1 :

Species: Human. Route: Synthetic Peptide

other info2 :

Immunogen: A synthetic peptide of human NCOA1. Calculated Molecular Weight: 157kDa

products categories :

Polyclonal

products description :

The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

ncbi gi num :

158518533

ncbi acc num :

Q15788.3

uniprot acc num :

Q15788

ncbi mol weight :

1441

ncbi pathways :

Activation Of Gene Expression By SREBF (SREBP) Pathway (685552); Adipogenesis Pathway (198832); Androgen Receptor Signaling Pathway (198806); BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway (477138); Bile Acid And Bile Salt Metabolism Pathway (106144); Biological Oxidations Pathway (105698); Circadian Clock Pathway (187173); Cytochrome P450 - Arranged By Substrate Type Pathway (105700); Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway (1127640); Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway (1127641)

ncbi summary :

uniprot summary :

SRC-1: a transcriptional coactivator for steroid and nuclear hormone receptors. A member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, and bHLH and PAS domains. Phosphorylated and activated via the mitogen-activated protein kinase pathway. Three alternatively spliced isoforms have been described. Protein type: DNA-binding; Acetyltransferase; Oncoprotein; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 2p23. Cellular Component: nucleoplasm; neuron projection; nuclear chromatin; cytoplasm. Molecular Function: ligand-dependent nuclear receptor binding; protein dimerization activity; transcription coactivator activity; protein N-terminus binding; retinoid X receptor binding; signal transducer activity; protein binding; histone acetyltransferase activity; enzyme binding; ligand-dependent nuclear receptor transcription coactivator activity; androgen receptor binding; protein complex binding; estrogen receptor binding; chromatin binding; progesterone receptor binding; nuclear hormone receptor binding. Biological Process: lactation; hypothalamus development; positive regulation of transcription from RNA polymerase II promoter by galactose; male mating behavior; intracellular receptor-mediated signaling pathway; response to retinoic acid; transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; male gonad development; hippocampus development; positive regulation of female receptivity; cellular lipid metabolic process; response to estradiol stimulus; cellular response to hormone stimulus; ovulation cycle; androgen receptor signaling pathway; cerebellum development; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; positive regulation of neuron differentiation; response to progesterone stimulus

size1 :

0.05 mL

price1 :

285 USD

size2 :

0.2 mL

price2 :

555

more info or order :

MyBioSource product webpage