product summary
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company name :
MyBioSource
product type :
antibody
product name :
BMP2 Polyclonal Antibody
catalog :
MBS125347
quantity :
0.05 mL
price :
200 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
image
image 1 :
Western blot analysis of extracts of various cell lines, using BMP2 Antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
image 2 :
Immunohistochemistry of paraffin-embedded human colon using BMP2 antibody at dilution of 1:200 (40x lens).
image 3 :
Immunohistochemistry of paraffin-embedded mouse lung using BMP2 antibody at dilution of 1:200 (40x lens).
product information
catalog number :
MBS125347
products type :
Antibody
products full name :
BMP2 Polyclonal Antibody
products short name :
[BMP2]
products name syn :
[bmp2; BMP 2A; BMP 2; BMP2A; bone morphogenetic protein 2; Bone morphogenetic protein 2A]
other names :
[Bone morphogenetic protein 2; Bone morphogenetic protein 2; bone morphogenetic protein 2; BMP-2A; bone morphogenetic protein 2A; bone morphogenetic protein 2; Bone morphogenetic protein 2A; BMP-2A]
products gene name :
[BMP2]
other gene names :
[BMP2; BMP2; BDA2; BMP2A; BMP2A; BMP-2; BMP-2A]
uniprot entry name :
BMP2_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
396
purity :
Affinity Purification
storage stability :
Store at -20°C. Avoid freeze / thaw cycles.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), Immuofluorescence (IF)
app notes :
WB: 1:500 - 1:2000. IHC: 1:50 - 1:100. IF 1:50-1:200
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Immunohistochemistry (IHC)
image4 heading :
Immunofluorescence (IF)
image4 description :
Immunofluorescence analysis of U2OS cells using BMP2 antibody (MBS125347) at dilution of 1:100. Blue: DAPI for nuclear staining
other info1 :
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
other info2 :
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 283-396 of human BMP2 (NP_001191.1). Calculated MW: 44kDa. Observed MW: 45 kDa
products categories :
Polyclonal
products description :
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients.
ncbi gi num :
115068
ncbi acc num :
P12643.1
uniprot acc num :
P12643
ncbi pathways :
Adipogenesis Pathway (198832); BDNF Signaling Pathway (712093); BMP Signaling Pathway (1084755); BMP Signaling Pathway (1108218); BMP Signalling And Regulation Pathway (198910); Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Elastic Fibre Formation Pathway (730310)
ncbi summary :
The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008]
uniprot summary :
Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
size1 :
0.05 mL
price1 :
200 USD
size2 :
0.1 mL
price2 :
275
size3 :
0.2 mL
price3 :
430
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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