antibody

NCAM1 Polyclonal Antibody

MBS125304

0.05 mL

285 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry, flow cytometry, FACS

Antibody

NCAM1 Polyclonal Antibody

NCAM1

CD56 NCAM: CD56; MSK39; NCAM

Neural cell adhesion molecule 1; Neural cell adhesion molecule 1; neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; antigen recognized by monoclonal antibody 5.1H11; neural cell adhesion molecule 1; CD_antigen: CD56

NCAM1

NCAM1; NCAM1; CD56; NCAM; MSK39; NCAM; N-CAM-1; NCAM-1

NCAM1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

858

Affinity Purification

1mg/ml

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

WB: 1:500 - 1:1000. IHC: 1:50 - 1:100. FC: 1:20 - 1:100

Species: Human. Immunogen: Recombinant Protein

Immunogen: Recombinant protein of human NCAM1. Calculated Molecular Weight: 95kD

Polyclonal

Neural cell adhesion molecule 1 (NCAM1, also known as CD56) is a cell adhesion glycoprotein of the immunoglobulin (Ig) superfamily. It is a multifunction protein involved in synaptic plasticity, neurodevelopment, and neurogenesis. NCAM1 is expressed on human neurones, glial cells, skeletal muscle cells, NK cells and a subset of T cells, and the expression is observed in a wide variety human tumors, including myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, and NK/T cell lymphomas. Three major isoforms of NCAM1, with molecular masses of 120, 140, and 180 kDa, are generated by alternative splicing of mRNA (PMID: 9696812). The glycosylphosphatidylinositol (GPI)-anchored NCAM120 and the transmembrane NCAM140 and NCAM180 consist of five Ig-like domains and two fibronection-type III repeats (FNIII). All three forms can be posttranslationally modified by addition of polysialic acid (PSA) (PMID: 14976519). Several other isofroms have also been described.

205830665

P13591.3

P13591

858

Axon Guidance Pathway (105688); BDNF Signaling Pathway (712093); Cardiac Progenitor Differentiation Pathway (712094); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cytokine Signaling In Immune System Pathway (366171); Developmental Biology Pathway (477129); ECM Proteoglycans Pathway (833812); Extracellular Matrix Organization Pathway (576262); FGF Signaling Pathway (137989)

This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

NCAM1: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, GPI anchor; Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 11q23.1. Cellular Component: Golgi membrane; cell surface; membrane; integral to membrane; plasma membrane; external side of plasma membrane. Molecular Function: identical protein binding. Biological Process: axon guidance; extracellular matrix organization and biogenesis; cytokine and chemokine mediated signaling pathway; cell adhesion

0.05 mL

285 USD

0.2 mL

555