catalog number :
MBS125223
products full name :
OLFM1 Polyclonal Antibody
products short name :
OLFM1
products name syn :
OLFM1; NOELIN1; AMY; olfactomedin 1; NOE1; Noelin
other names :
Noelin; Noelin; noelin; pancortin 1; olfactomedin-1; neuroblastoma protein; olfactomedin related ER localized protein; neuronal olfactomedin-related ER localized protein; olfactomedin 1; Neuronal olfactomedin-related ER localized protein; Olfactomedin-1
products gene name :
OLFM1
other gene names :
OLFM1; OLFM1; AMY; NOE1; OlfA; NOELIN1; NOE1; NOEL1
uniprot entry name :
NOE1_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Affinity Purification
storage stability :
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500 - 1:2000. IHC: 1:50 - 1:200
other info1 :
Species: Human. Route: Recombinant Protein
other info2 :
Immunogen: Recombinant Protein of human OLFM1. Calculated Molecular Weight: 55kDa
products categories :
Polyclonal
products description :
The Olfactomedin family comprises a diverse group of secreted glycoproteins, which includes OLFM1 (Noelin-1), OLFM2 (Noelin-2), OLFM3 (Noelin-3), OLFM4 (Noelin-4), tiarin, pancortin, gliomedin and mycocilin. These proteins are implicated in the development of the nervous system. Specifically, OLFM1 and OLFM2 expression is observed in the neural plate and neural crest, as well as in the cranial ganglia in mouse at E8-10, and later in brain tissue and in the zone of polarizing activity in the limb. Overexpression of OLFM1 causes an excess of neural crest emigrations and prolonged neural crest production. OLFM2 participates in the regulation of the development of the anterior nervous system. An Arg144Gln mutation in OLFM2 has been implicated as a possible cause for open-angle glaucoma (OAG).
ncbi summary :
This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]