product summary
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company name :
MyBioSource
product type :
antibody
product name :
AXL Polyclonal Antibody
catalog :
MBS125146
quantity :
0.05 mg
price :
285 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunoprecipitation
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS125146
products type :
Antibody
products full name :
AXL Polyclonal Antibody
products short name :
AXL
products name syn :
Axl: AXL; JTK11; UFO
other names :
Tyrosine-protein kinase receptor UFO; Tyrosine-protein kinase receptor UFO; tyrosine-protein kinase receptor UFO; AXL oncogene; AXL transforming sequence/gene; AXL receptor tyrosine kinase; AXL oncogene
products gene name :
AXL
other gene names :
AXL; AXL; ARK; UFO; JTK11; Tyro7; UFO
uniprot entry name :
UFO_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
894
purity :
Affinity Purification
concentration :
1mg/ml
storage stability :
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
tested application :
Western Blot (WB), Immunoprecipitation (IP)
app notes :
WB: 1:500 - 1:1000. IP: 1:20 - 1:50
other info1 :
Species: Human. Route: Recombinant Protein
other info2 :
Immunogen: Fusion protein of human AXL. Calculated Molecular Weight: 98kDa
products categories :
Polyclonal
products description :
Axl, Sky and Mer are three members of a receptor tyrosine kinase (RTK) family that share a conserved intracellular tyrosine kinase domain and an extracellular domain similar to those seen in cell adhesion molecules. These RTKs bind the vitamin K-dependent protein growth-arrest-specific 6 (Gas6), which is structurally related to the protein S anticoagulation factor (1). Upon binding to its receptor, Gas6 activates phosphatidylinositol 3-kinase (PI3K) and its downstream targets Akt and S6K, as well as NF-kappaB (2,3). A large body of evidence supports a role for Gas6/Axl signaling in cell growth and survival in normal and cancer cells (4).
ncbi gi num :
239938818
ncbi acc num :
P30530.3
uniprot acc num :
P30530
ncbi mol weight :
894
ncbi pathways :
Signal Transduction Pathway 477114!!Signaling By VEGF Pathway 106506!!VEGFA-VEGFR2 Pathway 1127512
ncbi summary :
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
size :
0.05 mg
price :
285 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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