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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Potassium channel subfamily K member 2
catalog :
MBS1249196
quantity :
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price :
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more info or order :
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product information
catalog number :
MBS1249196
products type :
Recombinant Protein
products full name :
Recombinant Human Potassium channel subfamily K member 2
products short name :
Potassium channel subfamily K member 2
products name syn :
Outward rectifying potassium channel protein TREK-1; TREK-1 K(+) channel subunit; Two pore domain potassium channel TREK-1; Two pore potassium channel TPKC1
other names :
potassium channel subfamily K member 2 isoform a; Potassium channel subfamily K member 2; potassium channel subfamily K member 2; potassium two pore domain channel subfamily K member 2; Outward rectifying potassium channel protein TREK-1; TREK-1 K(+) channel subunit; Two pore domain potassium channel TREK-1; Two pore potassium channel TPKC1
products gene name :
KCNK2
other gene names :
KCNK2; KCNK2; TREK; TPKC1; TREK1; K2p2.1; TREK-1; hTREK-1c; hTREK-1e; TREK; TREK1
uniprot entry name :
KCNK2_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
1-143
sequence length :
422
sequence :
MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFST
KPTVLASRVESDTTINVMKWKTVSTIFLVVVLYLIIGAT
VFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDEL
IQQIVAAINAGIIPLGNTSNQISHWD
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info2 :
Species: Homo sapiens (Human)
products categories :
Neuroscience
products description :
Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1
products references :
Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel." Meadows H.J., Benham C.D., Cairns W., Gloger I., Jennings C., Medhurst A.D., Murdock P., Chapman C.G. Pflugers Arch. 439:714-722(2000)
ncbi gi num :
62912487
ncbi acc num :
NP_001017424.1
ncbi gb acc num :
NM_001017424.2
uniprot acc num :
O95069
ncbi mol weight :
17.67KD
ncbi pathways :
Cardiac Conduction Pathway (1339115); Gastric Acid Secretion Pathway (154409); Gastric Acid Secretion Pathway (154383); Muscle Contraction Pathway (1269868); Neuronal System Pathway (1268763); Phase 4 - Resting Membrane Potential Pathway (1339116); Potassium Channels Pathway (1268821); TWIK Related Potassium Channel (TREK) Pathway (1268833); Tandem Pore Domain Potassium Channels Pathway (1268831)
ncbi summary :
This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
size1 :
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price1 :
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more info or order :
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company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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