protein

Recombinant Human HLA class I histocompatibility antigen, alpha chain E

MBS1243965

0.05 mg (E-Coli)

190 USD

Recombinant Protein

Recombinant Human HLA class I histocompatibility antigen, alpha chain E

HLA class I histocompatibility antigen, alpha chain E

MHC class I antigen E

HLA class I histocompatibility antigen, alpha chain E; HLA class I histocompatibility antigen, alpha chain E; HLA class I histocompatibility antigen, alpha chain E; major histocompatibility complex, class I, E; MHC class I antigen E

HLA-E

HLA-E; HLA-E; MHC; QA1; EA1.2; EA2.1; HLA-6.2; HLA-6.2; HLAE

HLAE_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

22-305, Partial, provide the complete extracellular domain.

305

GSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDND
AASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNL
RTLRGYYNQSEAGSHTLQWMHGCELGPDRRFLRGYEQFA
YDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQ
RAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPIS
DHEATLRCWALGFYPAEITLTWQQDGEGHTQDTELVETR
PAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLR
WKPASQPTIPI

Greater than 90% as determined by SDS-PAGE.

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Immunology

Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules.

Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene.Mizuno S., Trapani J.A., Koller B.H., Dupont B., Yang S.Y.J. Immunol. 140:4024-4030(1988) Cell surface expression of HLA-E interaction with human beta-2 microglobulin and allelic differences.Ulbrecht M., Courturier A., Martinozzi S., Pla M., Srivastava R., Peterson P.A., Weiss E.H.3.0.CO;2-6>Eur. J. Immunol. 29:537-547(1999) HLA-E, F, and G polymorphism genomic sequence defines new variation spanning the nonclassical class I genes.Ishitani A., Miki A., Williams L.M., Moore Y., Geraghty D.E.Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.Shiina S., Tamiya G., Oka A., Inoko H. HLA-E. A novel HLA class I gene expressed in resting T lymphocytes.Koller B.H., Geraghty D.E., Shimizu Y., Demars R., Orr H.T.J. Immunol. 141:897-904(1988) Ulbrecht M.A new variant of HLA-E*010303 with three synonymous mutations.He X., Xu L., Liu Y., Zeng Y.Cloning of HLA-E cDNA from activated peripheral leukocytes.He X., Xu L., Liu Y., Zeng Y.Polymorphism in the human class I MHC locus HLA-E in Japanese.Ohya K., Kondo K., Mizuno S.Immunogenetics 32:205-209(1990) Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.Nat. Biotechnol. 27:378-386(2009) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E.O'Callaghan C.A., Tormo J., Willcox B.E., Braud V.M., Jakobsen B.K., Stuart D.I., McMichael A.J., Bell J.I., Jones E.Y.Mol. Cell 1:531-541(1998) Definitive high resolution typing of HLA-E allelic polymorphisms identifying potential errors in existing allele data.Grimsley C., Kawasaki A., Gassner C., Sageshima N., Nose Y., Hatake K., Geraghty D.E., Ishitani A.Tissue Antigens 60:206-212(2002)

62912479

NP_005507.3

NP_005507.3

P13747

48.67kD

Adaptive Immune System Pathway (1269171); Allograft Rejection Pathway (920963); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (1269194); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (1269195); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533)

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]

HLA-E: Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules. Belongs to the MHC class I family. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: cell surface; early endosome membrane; Golgi membrane; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane. Molecular Function: beta-2-microglobulin binding; MHC class I protein binding; natural killer cell lectin-like receptor binding; peptide antigen binding; receptor binding. Biological Process: adaptive immune response; antibacterial humoral response; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of peptide antigen via MHC class I; cytokine and chemokine mediated signaling pathway; defense response to Gram-positive bacterium; innate immune response; positive regulation of immunoglobulin secretion; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of natural killer cell mediated immunity; positive regulation of T cell mediated cytotoxicity; positive regulation of TRAIL production; positive regulation of tumor necrosis factor production; protection from natural killer cell mediated cytotoxicity; regulation of immune response; regulation of natural killer cell mediated immunity

0.05 mg (E-Coli)

190 USD

0.2 mg (E-Coli)

460

0.5 mg (E-Coli)

750

0.05 mg (Baculovirus)

950

0.05 mg (Mammalian-Cell)

1170