product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Beta-1 adrenergic receptor
catalog :
MBS1236894
quantity :
0.05 mg (E-Coli)
price :
190 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1236894
products type :
Recombinant Protein
products full name :
Recombinant Human Beta-1 adrenergic receptor
products short name :
Beta-1 adrenergic receptor
other names :
beta-1 adrenergic receptor; Beta-1 adrenergic receptor; beta-1 adrenergic receptor; adrenoceptor beta 1; Beta-1 adrenoreceptor; Beta-1 adrenoceptor
products gene name :
ADRB1
other gene names :
ADRB1; ADRB1; RHR; B1AR; ADRB1R; BETA1AR; ADRB1R; B1AR; Beta-1 adrenoceptor
uniprot entry name :
ADRB1_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
378-477
sequence length :
477
sequence :
CRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLA
RPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGA
AADSDSSLDEPCRPGFASESKV
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
products categories :
Cardiovascular
ncbi gi num :
4557265
ncbi acc num :
NP_000675.1
ncbi gb acc num :
NM_000684.2
uniprot acc num :
P08588
ncbi mol weight :
12.5kD
ncbi pathways :
Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Adrenoceptors Pathway (1269555); Amine Ligand-binding Receptors Pathway (1269553); Calcium Regulation In The Cardiac Cell Pathway (198906); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285)
ncbi summary :
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]
uniprot summary :
ADRB1: a GPCR-coupled 7 transmembrane receptor that binds epinephrine and norepinephrine with approximately equal affinity. Mediates the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Interacts with PIST and PSD-95. Localized at the plasma membrane and in the Golgi upon PIST overexpression. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1. Chromosomal Location of Human Ortholog: 10q25.3. Cellular Component: early endosome; integral to plasma membrane; plasma membrane. Molecular Function: alpha-2A adrenergic receptor binding; beta-adrenergic receptor activity; beta1-adrenergic receptor activity; epinephrine binding; norepinephrine binding; PDZ domain binding; protein binding; protein heterodimerization activity; Ras guanyl-nucleotide exchange factor activity; receptor signaling protein activity. Biological Process: adenylate cyclase activation; brown fat cell differentiation; cell-cell signaling; diet induced thermogenesis; fear response; heat generation; negative regulation of multicellular organism growth; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of cAMP biosynthetic process; positive regulation of GTPase activity; positive regulation of heart rate by epinephrine-norepinephrine; positive regulation of the force of heart contraction by epinephrine-norepinephrine; response to cold; thermoregulation. Disease: Resting Heart Rate, Variation In
size1 :
0.05 mg (E-Coli)
price1 :
190 USD
size2 :
0.2 mg (E-Coli)
price2 :
460
size3 :
0.5 mg (E-Coli)
price3 :
750
size4 :
1 mg (E-Coli)
price4 :
1180
size5 :
1 mg (Yeast)
price5 :
1390
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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