product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Neuronal migration protein doublecortin
catalog :
MBS1224668
quantity :
0.01 mg (E-Coli)
price :
135 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1224668
products type :
Recombinant Protein
products full name :
Recombinant Human Neuronal migration protein doublecortin
products short name :
Neuronal migration protein doublecortin
products name syn :
Doublin; Lissencephalin-X; Lis-X
other names :
neuronal migration protein doublecortin isoform a; Neuronal migration protein doublecortin; neuronal migration protein doublecortin; doublecortin; Doublin; Lissencephalin-X; Lis-X
products gene name :
DCX
other gene names :
DCX; DCX; DC; DBCN; LISX; SCLH; XLIS; DBCN; LISX; Lis-X
uniprot entry name :
DCX_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
1-441
sequence length :
441
sequence :
MKTLPLHSHCTEMQRLLPKLEMLTLGSSFCSLQGEFCQA
MDSFTTVSHVGMCEETDASFNVFSPKFQFDRSHCQSLRF
HQNMELDFGHFDERDKTSRNMRGSRMNGLPSPTHSAHCS
FYRTRTLQALSNEKKAKKVRFYRNGDRYFKGIVYAVSSD
RFRSFDALLADLTRSLSDNINLPQGVRYIYTIDGSRKIG
SMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTS
ANMKAPQSLASSNSAQARENKDFVRPKLVTIIRSGVKPR
KAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKKLYTL
DGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENE
CRVMKGNPSATAGPKASPTPQKTSAKSPGPMRRSKSPAD
SANGTSSSQLSTPKSKQSPISTPTSPGSLRKHKDLYLPL
SLDDSDSLGDSM
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info2 :
Species: Homo sapiens (Human)
products categories :
Neuroscience
products description :
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.
products references :
A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome." Des Portes V., Pinard J.-M., Billuart P., Vinet M.-C., Koulakoff A., Carrie A., Gelot A., Dupuis E., Motte J., Berwald-Netter Y., Catala M., Kahn A., Beldjord C., Chelly J. Cell 92:51-61(1998)
ncbi gi num :
30181246
ncbi acc num :
NP_000546.2
ncbi gb acc num :
NM_000555.3
uniprot acc num :
O43602
ncbi mol weight :
65.29kD
ncbi pathways :
Axon Guidance Pathway (1270303); Developmental Biology Pathway (1270302); L1CAM Interactions Pathway (1270323); Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway (137984); Neurofascin Interactions Pathway (1270328)
ncbi summary :
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
size1 :
0.01 mg (E-Coli)
price1 :
135 USD
size2 :
0.05 mg (E-Coli)
price2 :
255
size3 :
0.2 mg (E-Coli)
price3 :
665
size4 :
0.5 mg (E-Coli)
price4 :
1090
size5 :
0.05 mg (Baculovirus)
price5 :
1220
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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