protein

Recombinant Varicella-zoster virus Envelope glycoprotein I (gI)

MBS1221594

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Recombinant Protein

Recombinant Varicella-zoster virus Envelope glycoprotein I (gI)

Envelope glycoprotein I (gI)

Recombinant Envelope glycoprotein I (gI); Envelope glycoprotein I; gI; Glycoprotein IV; GPIV

envelope glycoprotein I; Envelope glycoprotein I; type 1 membrane protein; contains a signal peptide; complexed with envelope glycoprotein E to form an Fc-receptor; envelope glycoprotein I; Glycoprotein IV

gI; ORF67

ORF67; gI; gI; GPIV

GI_VZVD

E Coli or Yeast or Baculovirus or Mammalian Cell

18-295

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Species: Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)

9625941

NP_040189.1

NC_001348.1

P09258

39,364 Da

Function: In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips . By similarity.The heterodimer gE/gI serves as a receptor for the Fc part of human IgG. Dissociation of gE/gI from IgG occurs at acidic pH. May thus be involved in anti-VZV antibodies bipolar bridging, followed by intracellular endocytosis and degradation, thereby interfering with host Ig-mediated immune responses . By similarity. Subunit structure: Interacts with gE; this interaction enhances the Fc receptor function of gE . By similarity. Subcellular location: Virion membrane; Single-pass membrane protein . By similarity. Host cell membrane; Single-pass type I membrane protein . Potential. Host cell junction . By similarity. Host Golgi apparatus membrane; Single-pass type I membrane protein . By similarity. Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). The heterodimer gE/gI then redistribute to cell junctions to promote cell-cell spread later in the infection . By similarity. Sequence similarities: Belongs to the alphaherpesvirinae glycoprotein I family.

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