antibody

Mouse monoclonal antibody Anti-Human SOX4

MBS120428

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

154C4a

Antibody

Mouse monoclonal antibody Anti-Human SOX4

SOX4

Homo sapiens SRY (sex determining region Y)-box 4 (SOX4), mRNA.; EVI16

Homo sapiens SRY (sex determining region Y)-box 4 (SOX4), mRNA; Transcription factor SOX-4; transcription factor SOX-4; SRY-related HMG-box gene 4; ecotropic viral integration site 16; SRY (sex determining region Y)-box 4

SOX4

SOX4; SOX4; EVI16

SOX4_HUMAN

Monoclonal

IgG2a

154C4a

Mouse

Human

4912

100 ug/ml (1.0 ml)

Dot Blot (DB), Immunocytochemistry (ICC)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.[NCBI Entrez Gene Summary

30179901

NP_003098.1

NM_003107

47,263 Da

IL-5 Signaling Pathway (198770); MicroRNAs In Cancer Pathway (852705); MicroRNAs In Cancer Pathway (852928)

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008]

SOX4: Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5 -AACAAAG-3 motif. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 6p22.3. Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus. Molecular Function: protein binding; protein heterodimerization activity; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; negative regulation of protein export from nucleus; positive regulation of translation; positive regulation of apoptosis; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; heart development; regulation of protein stability; Wnt receptor signaling pathway through beta-catenin; glucose homeostasis; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; glial cell proliferation; negative regulation of cell proliferation; sympathetic nervous system development; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; skeletal development; positive regulation of Wnt receptor signaling pathway; T cell differentiation; glial cell development; pro-B cell differentiation; protein stabilization; positive regulation of insulin secretion; DNA damage response, detection of DNA damage; spinal cord motor neuron differentiation; endocrine pancreas development; limb bud formation; spinal cord development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein ubiquitination; neural tube formation

0.1 mg

345 USD