product summary
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company name :
MyBioSource
product type :
antibody
product name :
Mouse monoclonal antibody Anti-Human HAND2
catalog :
MBS120421
quantity :
0.1 mg
price :
345 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
HAND2C1a
reactivity :
human
application :
western blot, dot blot
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS120421
products type :
Antibody
products full name :
Mouse monoclonal antibody Anti-Human HAND2
products short name :
HAND2
products name syn :
Homo sapiens heart and neural crest derivatives expressed 2 (HAND2), mRNA.; Hed; dHand; DHAND2; Thing2; FLJ16260; MGC125303; MGC125304
other names :
Homo sapiens heart and neural crest derivatives expressed 2 (HAND2), mRNA; heart- and neural crest derivatives-expressed protein 2; basic helix-loop-helix transcription factor HAND2; class A basic helix-loop-helix protein 26; deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; heart and neural crest derivatives expressed 2
products gene name :
HAND2
other gene names :
HAND2; HAND2; Hed; dHand; DHAND2; Thing2; bHLHa26
uniprot entry name :
HAND2_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
HAND2C1a
host :
Mouse
reactivity :
Human
sequence length :
2368
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.[NCBI Entrez Gene Summary]
ncbi gi num :
88999597
ncbi acc num :
NP_068808.1
ncbi gb acc num :
NM_021973
ncbi mol weight :
20,269 Da
ncbi pathways :
Heart Development Pathway (198802)
ncbi summary :
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul 2008]
uniprot summary :
HAND2: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5 -CANNTG-3 . Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 4q33. Cellular Component: transcription factor complex; protein complex; nuclear chromatin. Molecular Function: protein binding; protein homodimerization activity; transcription activator binding; AT DNA binding; protein heterodimerization activity; transcription coactivator activity; transcription factor binding. Biological Process: heart morphogenesis; adult heart development; tongue development; thymus development; transcription, DNA-dependent; neural crest cell development; in utero embryonic development; apoptosis; negative regulation of transcription factor activity; heart development; positive regulation of transcription, DNA-dependent; mesenchymal cell proliferation; palate development; negative regulation of DNA binding; odontogenesis of dentine-containing teeth; peripheral nervous system neuron development; sympathetic nervous system development; regulation of transcription, DNA-dependent; suckling behavior; negative regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; heart looping; angiogenesis; embryonic digit morphogenesis
size1 :
0.1 mg
price1 :
345 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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