catalog number :
MBS120420
products full name :
Mouse monoclonal antibody Anti-Human LMO1
products short name :
LMO1
products name syn :
Homo sapiens LIM domain only 1 (rhombotin 1), mRNA (cDNA clone MGC:116691 IMAGE:40000076), complete cds.; RHOM1; TTG1
other names :
Homo sapiens LIM domain only 1 (rhombotin 1), mRNA; Rhombotin-1; rhombotin-1; LIM domain only protein 1; LMO-1; T-cell translocation gene 1; T-cell translocation protein 1; cysteine-rich protein TTG-1; LIM domain only 1 (rhombotin 1); Cysteine-rich protein TTG-1; LIM domain only protein 1; LMO-1; T-cell translocation protein 1
products gene name :
LMO1
other gene names :
LMO1; LMO1; TTG1; RBTN1; RHOM1
uniprot entry name :
RBTN1_HUMAN
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB), Immunocytochemistry (ICC)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
LMO1 enocdes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted.[NCBI Entrez Gene Summary]
ncbi mol weight :
17,697 Da
ncbi summary :
This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]