antibody

Mouse monoclonal antibody Anti-Human CCNE1

MBS120411

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

2121C1a

Antibody

Mouse monoclonal antibody Anti-Human CCNE1

CCNE1

Homo sapiens cyclin E1 (CCNE1), transcript variant 1, mRNA.; CCNE

Homo sapiens cyclin E1 (CCNE1), mRNA; G1/S-specific cyclin-E1; G1/S-specific cyclin-E1; cyclin E variant ex5del; cyclin E variant ex7del; cyclin Es; cyclin Et; cyclin E1

CCNE1

CCNE1; CCNE1; CCNE

CCNE1_HUMAN

Monoclonal

IgG1

2121C1a

Mouse

Human

2021

100 ug/ml (1.0 ml)

Dot Blot (DB), Western Blot (WB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.[NCBI Entrez Gene Summary]

339275820

NP_001229.1

NM_001238

45,150 Da

Androgen Receptor Signaling Pathway 198806!!B Cell Receptor Signaling Pathway 198909!!BARD1 Signaling Events Pathway 137959!!Cell Cycle Pathway 530733!!Cell Cycle Checkpoints Pathway 105739!!Cell Cycle, Mitotic Pathway 105765!!Cell Cycle Pathway 198811!!Cell Cycle Pathway 83054!!Cell Cycle Pathway 463!!Cell Cycle - G1/S Transition Pathway 1084768

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD