antibody

Mouse monoclonal antibody Anti-Human ID1

MBS120402

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

2456C1a

Antibody

Mouse monoclonal antibody Anti-Human ID1

ID1

Homo sapiens inhibitor of DNA binding 1, dominant negative helixloop-helix protein (ID1), transcript variant 1, mRNA.; ID

Homo sapiens inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (ID1), transcript variant 1, mRNA; DNA-binding protein inhibitor ID-1; DNA-binding protein inhibitor ID-1; class B basic helix-loop-helix protein 24; dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein); inhibitor of differentiation 1; inhibitor of DNA binding 1, dominant negative helix-loop-helix protein; Class B basic helix-loop-helix protein 24; bHLHb24; Inhibitor of DNA binding 1; Inhibitor of differentiation 1

ID1

ID1; ID1; ID; bHLHb24

ID1_HUMAN

Monoclonal

IgG1

2456C1a

Mouse

Human

1000

100 ug/ml (1.0 ml)

Dot Blot (DB), Immunocytochemistry (ICC)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene.[NCBI Entrez Gene Summary]

341865544

NP_002156.2

NM_002165

15,586 Da

ALK1 Signaling Events Pathway (137968); Cellular Senescence Pathway (905991); Cellular Responses To Stress Pathway (645258); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); IL-3 Signaling Pathway (198881); Id Signaling Pathway (198871); Neural Crest Differentiation Pathway (672460); Notch-mediated HES/HEY Network Pathway (169347); Oncogene Induced Senescence Pathway (905992)

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ID1: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. 2 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 20q11. Cellular Component: nucleoplasm; Golgi apparatus; nucleus. Molecular Function: protein dimerization activity; protein binding; transcription factor activity. Biological Process: circadian rhythm; transcription, DNA-dependent; collagen metabolic process; protein destabilization; blood vessel endothelial cell migration; negative regulation of transcription factor activity; heart development; negative regulation of transcription from RNA polymerase II promoter; regulation of angiogenesis; negative regulation of DNA binding; BMP signaling pathway; response to antibiotic; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway; blood vessel morphogenesis; negative regulation of osteoblast differentiation; angiogenesis; endothelial cell morphogenesis; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis

0.1 mg

345 USD