catalog number :
MBS120396
products full name :
Mouse monoclonal antibody Anti-Human HR
products name syn :
Homo sapiens hairless homolog (mouse), mRNA (cDNA clone MGC:70516 IMAGE:6138631), complete cds.; HSA277165; AU
other names :
Homo sapiens hairless homolog (mouse), mRNA; Lysine-specific demethylase hairless; lysine-specific demethylase hairless; hairless homolog; protein hairless; hair growth associated
other gene names :
HR; HR; AU; MUHH; ALUNC; HYPT4; MUHH1; HSA277165
uniprot entry name :
HAIR_HUMAN
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB), Immunocytochemistry (ICC)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
This gene encodes a protein whose function has been linked to hair growth. A similar protein in rat functions as a transcriptional corepressor for thyroid hormone and interacts with histone deacetylases. Mutations in this gene have been documented in cases of autosomal recessive congenital alopecia and atrichia with papular lesions.[NCBI Entrez Gene Summary]
ncbi mol weight :
121,857 Da
ncbi summary :
This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]