Mouse monoclonal antibody Anti-Human PRKAR1A | MyBioSource MBS120384 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody Anti-Human PRKAR1A

catalog :

MBS120384

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3546C2a

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS120384

products type :

Antibody

products full name :

Mouse monoclonal antibody Anti-Human PRKAR1A

products short name :

PRKAR1A

products name syn :

Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), transcript variant 1, mRNA.; CAR; CNC; CNC1; PKR1; TSE1; PPNAD1; PRKAR1; MGC17251; DKFZp779L0468

other names :

Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (PRKAR1A), transcript variant 1, mRNA; cAMP-dependent protein kinase type I-alpha regulatory subunit; cAMP-dependent protein kinase type I-alpha regulatory subunit; Carney complex type 1; cAMP-dependent protein kinase regulatory subunit RIalpha; cAMP-dependent protein kinase type I-alpha regulatory chain; protein kinase A type 1a regulatory subunit; tissue-specific extinguisher 1; protein kinase, cAMP-dependent, regulatory, type I, alpha; Tissue-specific extinguisher 1; TSE1

products gene name :

PRKAR1A

other gene names :

PRKAR1A; PRKAR1A; CAR; CNC; CNC1; PKR1; TSE1; ADOHR; PPNAD1; PRKAR1; ACRDYS1

uniprot entry name :

KAP0_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

3546C2a

host :

Mouse

reactivity :

Human

sequence length :

4325

concentration :

100 ug/ml (1.0 ml)

tested application :

Dot Blot (DB), Western Blot (WB)

other info1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

other info2 :

Sterility: Filtered through a 0.22 um membrane.

products description :

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Functional null mutations in this gene cause Carney complex (CNC), an autosomal dominant multiple neoplasia syndrome. This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. Three alternatively spliced transcript variants encoding the same protein have been observed. [NCBI Entrez Gene Summary]

ncbi gi num :

443497962

ncbi acc num :

NP_002725.1

ncbi gb acc num :

NM_002734

ncbi mol weight :

38,003 Da

ncbi pathways :

Apoptosis Pathway 83060!!Apoptosis Pathway 470!!Aquaporin-mediated Transport Pathway 187187!!Ca-dependent Events Pathway 106497!!CaM Pathway 106468!!Calcium Regulation In The Cardiac Cell Pathway 198906!!Calmodulin Induced Events Pathway 106469!!DAG And IP3 Signaling Pathway 477115!!DAP12 Interactions Pathway 685549!!DAP12 Signaling Pathway 685550

ncbi summary :

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]

size :

0.1 mg

price :

345 USD

more info or order :

MyBioSource product webpage