Mouse monoclonal antibody Anti-Human PER1 | MyBioSource MBS120361 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody Anti-Human PER1

catalog :

MBS120361

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2715C2

reactivity :

human

application :

western blot, dot blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS120361

products type :

Antibody

products full name :

Mouse monoclonal antibody Anti-Human PER1

products short name :

PER1

products name syn :

Homo sapiens period homolog 1 (Drosophila) ; PER; hPER; RIGUI; MGC88021

other names :

Homo sapiens period circadian clock 1 (PER1), mRNA; Period circadian protein homolog 1; period circadian protein homolog 1; Period, drosophila, homolog of; circadian clock protein PERIOD 1; circadian pacemaker protein RIGUI; hPER1; period homolog 1; period circadian clock 1; Circadian clock protein PERIOD 1; Circadian pacemaker protein Rigui

products gene name :

PER1

other gene names :

PER1; PER1; PER; hPER; RIGUI

uniprot entry name :

PER1_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

2715C2

host :

Mouse

reactivity :

Human

sequence length :

4717

concentration :

100 ug/ml (1.0 ml)

tested application :

Dot Blot (DB)

other info1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

other info2 :

Sterility: Filtered through a 0.22 um membrane.

products description :

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [NCBI Entrez Gene Summary]

ncbi gi num :

194097340

ncbi acc num :

NP_002607.2

ncbi gb acc num :

NM_002616

ncbi mol weight :

ncbi pathways :

BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway (477138); Circadian Clock Pathway (187173); Circadian Entrainment Pathway (698773); Circadian Entrainment Pathway (699872); Circadian Rhythm Pathway (83084); Circadian Rhythm Pathway (495); Circadian Rhythm Pathway (137978); Diurnally Regulated Genes With Circadian Orthologs Pathway (198813); Herpes Simplex Infection Pathway (377873); Herpes Simplex Infection Pathway (377865)

ncbi summary :

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [provided by RefSeq, Jan 2014]

uniprot summary :

PER1: Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK NPAS2-BMAL1 BMAL2-induced transactivation. Can bind heme. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: cytoplasm; nucleus. Molecular Function: signal transducer activity; chromatin DNA binding; ubiquitin protein ligase binding; kinase binding; transcription factor binding. Biological Process: circadian rhythm; negative regulation of JNK cascade; response to cAMP; transcription, DNA-dependent; regulation of sodium ion transport; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription from RNA polymerase II promoter; regulation of circadian rhythm; signal transduction; entrainment of circadian clock by photoperiod; positive regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; entrainment of circadian clock; negative regulation of transcription, DNA-dependent; regulation of hair cycle

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage