antibody

Mouse monoclonal antibody Anti-Human TRIOBP

MBS120359

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

2438C1a

Antibody

Mouse monoclonal antibody Anti-Human TRIOBP

TRIOBP

Homo sapiens TRIO and F-actin binding protein; TARA; DFNB28; FLJ39315; KIAA1662; dJ37E16.4; HRIHFB2122

Homo sapiens TRIO and F-actin binding protein (TRIOBP), transcript variant 1, mRNA; TRIO and F-actin-binding protein; TRIO and F-actin-binding protein; protein Tara; tara-like protein; trio-associated repeat on actin; TRIO and F-actin binding protein; Protein Tara; Trio-associated repeat on actin

TRIOBP

TRIOBP; TRIOBP; TARA; TAP68; DFNB28; dJ37E16.4; HRIHFB2122

TARA_HUMAN

Monoclonal

IgG1

2438C1a

Mouse

Human

4753

100 ug/ml (1.0 ml)

Dot Blot (DB), Western Blot (WB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. This trio-binding protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [NCBI Entrez Gene Summary]

88501739

NP_008963.3

NM_007032

74,048 Da

This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]

Tara: May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. Defects in TRIOBP are the cause of deafness autosomal recessive type 28 (DFNB28). 5 isoforms of the human protein are produced by alternative splicing. Protein type: Cytoskeletal; Actin-binding; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 22q13.1. Cellular Component: focal adhesion; cytoplasm; microtubule organizing center; midbody; nucleus; actin cytoskeleton. Molecular Function: actin filament binding; ubiquitin protein ligase binding; GTP-Rho binding; myosin II binding. Biological Process: mitosis; actin modification; cell division; barbed-end actin filament capping. Disease: Deafness, Autosomal Recessive 28

0.1 mg

345 USD