Recombinant Human TYRO protein tyrosine kinase-binding protein (TYROBP) | MyBioSource MBS1203589 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human TYRO protein tyrosine kinase-binding protein (TYROBP)

catalog :

MBS1203589

quantity :

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product information

catalog number :

MBS1203589

products type :

Recombinant Protein

products full name :

Recombinant Human TYRO protein tyrosine kinase-binding protein (TYROBP)

products short name :

TYRO protein tyrosine kinase-binding protein (TYROBP)

products name syn :

Recombinant TYRO protein tyrosine kinase-binding protein (TYROBP); TYRO protein tyrosine kinase-binding protein; DNAX-activation protein 12 Killer-activating receptor-associated protein; KAR-associated protein

other names :

TYRO protein tyrosine kinase-binding protein isoform 1; TYRO protein tyrosine kinase-binding protein; TYRO protein tyrosine kinase-binding protein; KAR-associated protein; DNAX-activation protein 12; killer activating receptor associated protein; killer-activating receptor-associated protein; TYRO protein tyrosine kinase binding protein; DNAX-activation protein 12; Killer-activating receptor-associated protein

products gene name syn :

TYROBP; DAP12, KARAP

other gene names :

TYROBP; TYROBP; DAP12; KARAP; PLOSL; DAP12; KARAP; KAR-associated protein

uniprot entry name :

TYOBP_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

22-40

sequence length :

113

sequence :

LRPVQAQAQSDCSCSTVSP

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

other info1 :

Species: Homo sapiens (Human)

ncbi gi num :

4507755

ncbi acc num :

NP_003323.1

ncbi gb acc num :

NM_003332.3

uniprot acc num :

O43914

ncbi mol weight :

12,179 Da

ncbi pathways :

Adaptive Immunity Signaling Pathway (366160); Axon Guidance Pathway (105688); Cell Junction Organization Pathway (160966); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413); Interactions Of The Immunoglobulin Superfamily (IgSF) Member Proteins Pathway (187227); Natural Killer Cell Mediated Cytotoxicity Pathway (83079); Natural Killer Cell Mediated Cytotoxicity Pathway (490); Osteoclast Differentiation Pathway (193147); Osteoclast Differentiation Pathway (193096)

ncbi summary :

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

uniprot summary :

TYROBP: Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. Defects in TYROBP are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. Belongs to the TYROBP family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Cell surface. Chromosomal Location of Human Ortholog: 19q13.1. Cellular Component: cell surface; integral to plasma membrane; plasma membrane. Molecular Function: identical protein binding; protein binding; receptor signaling protein activity; receptor binding. Biological Process: integrin-mediated signaling pathway; axon guidance; neutrophil activation during immune response; regulation of immune response; macrophage activation during immune response; cellular defense response; innate immune response; signal transduction. Disease: Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

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