antibody

Mouse monoclonal antibody Anti-Human CTCF

MBS120356

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

252C3a

Antibody

Mouse monoclonal antibody Anti-Human CTCF

CTCF

Homo sapiens CCCTC-binding factor (zinc finger protein)

Homo sapiens CCCTC-binding factor (zinc finger protein), mRNA; Transcriptional repressor CTCF; transcriptional repressor CTCF; 11 zinc finger transcriptional repressor; 11-zinc finger protein; CTCFL paralog; CCCTC-binding factor (zinc finger protein); 11-zinc finger protein; CCCTC-binding factor; CTCFL paralog

CTCF

CTCF; CTCF; MRD21

CTCF_HUMAN

Monoclonal

IgG1

252C3a

Mouse

Human

3460

100 ug/ml (1.0 ml)

Dot Blot (DB), Immunocytochemistry (ICC)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. [NCBI Entrez Gene Summary]

33878521

BC014267

45,998 Da

SIDS Susceptibility Pathways (198901); TGF-beta Receptor Signaling Pathway (198774)

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

CTCF: a widely expressed, sequence-specific DNA-binding transcriptional regulator, insulator, and organizer of higher-order chromatin structure. Acts as a tumor suppressor. Contains 11 C2H2-type zinc fingers. Involved in promoter activation or repression, hormone-responsive gene silencing, methylation-dependent chromatin insulation, and genomic imprinting. Mediates pairing between X chromosomes and interactions between distant regulatory elements. Binds to promoters of c-myc, PLK, PIM1 and APP. A critical regulator of cell-cycle arrest and death after B cell receptor signaling in immature B cells. CTCF, together with YY1 and Tsix, form a regulated epigenetic switch for X-inactivation. Protein type: Transcription factor; Tumor suppressor; C2H2-type zinc finger protein. Chromosomal Location of Human Ortholog: 16q21-q22.3. Cellular Component: nucleoplasm; nucleolus; condensed chromosome; nucleus; chromosome, pericentric region. Molecular Function: protein binding; zinc ion binding; chromatin insulator sequence binding; sequence-specific DNA binding; transcription factor activity; transcription corepressor activity. Biological Process: genetic imprinting; transcription, DNA-dependent; maintenance of DNA methylation; positive regulation of transcription, DNA-dependent; regulation of histone methylation; regulation of histone acetylation; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic; nucleosome positioning; chromosome segregation; regulation of molecular function, epigenetic; DNA methylation; negative regulation of transcription, DNA-dependent. Disease: Mental Retardation, Autosomal Dominant 21

0.1 mg

345 USD