antibody

Mouse monoclonal antibody Anti-Human FOXM1

MBS120349

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

263C2a

western blot, immunocytochemistry

Antibody

Mouse monoclonal antibody Anti-Human FOXM1

FOXM1

Homo sapiens forkhead box M1; MPP2; HFH11; HNF-3; INS-1; MPP-2; PIG29; FKHL16; FOXM1B; HFH-11; TRIDENT; MPHOSPH2

Homo sapiens forkhead box M1 (FOXM1), transcript variant 2, mRNA; Forkhead box protein M1; forkhead box protein M1; Forkhead, drosophila, homolog-like 16; HNF-3/fork-head homolog 11; M-phase phosphoprotein 2; MPM-2 reactive phosphoprotein 2; forkhead-related protein FKHL16; hepatocyte nuclear factor 3 forkhead homolog 11; transcription factor Trident; winged-helix factor from INS-1 cells; forkhead box M1; Forkhead-related protein FKHL16; Hepatocyte nuclear factor 3 forkhead homolog 11; HFH-11; HNF-3/fork-head homolog 11; M-phase phosphoprotein 2; MPM-2 reactive phosphoprotein 2; Transcription factor Trident; Winged-helix factor from INS-1 cells

FOXM1

FOXM1; FOXM1; MPP2; TGT3; HFH11; HNF-3; INS-1; MPP-2; PIG29; FKHL16; FOXM1B; HFH-11; TRIDENT; MPHOSPH2

FOXM1_HUMAN

Monoclonal

IgG1

263C2a

Mouse

Human

3551

Mouse monoclonal anti-human FOXM1 antibody in PBS (3.0 mM KCl, 1.5 mM KH2PO4, 140 mM NaCl, 8.0 mM Na2HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3).

100 ug/ml (1.0 ml)

Store at 2-8 degree C for up to one year. We recommended storing at -20 degree C for long-term storage. Avoid repeat freezing and thawing cycles.

Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)

WB:0.2-2ug/ml

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane. Disposal: This antibody solution contains sodium azide (NaN3) as a preservative. There is a potential hazard that NaN3 reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. Safety warnings and precautions: Caution must be taken to avoid contact with skin or eyes. In such a case, rinse thoroughly at once with water.Do not ingest, inhale, or swallow. Seek medical attention immediately. Wear appropriate protective clothing such as laboratory overalls, safety glasses and gloves. It is strongly advised that this product should be handled by people who have been well trained in laboratory techniques and that it is handled with care pursuant to the principles of good laboratory practice. All chemicals are deemed potentially harmful. The vial is prone to fall over. Use caution, especially when the lid is off.

Transcriptional activatory factor. May play a role in the control of cell proliferation. [UniProtKB Function]

340545540

NP_068772.2

NM_021953

Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Cyclin A/B1 Associated Events During G2/M Transition Pathway (105802); FOXM1 Transcription Factor Network Pathway (137935); G2/M Transition Pathway (105801); Mitotic G2-G2/M Phases Pathway (160942); Polo-like Kinase Mediated Events Pathway (105806); SIDS Susceptibility Pathways (198901)

The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

FOXM1: a transcriptional activator factor. Contains 1 fork-head domain. May play a role in the control of cell proliferation. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Phosphorylated in M (mitotic) phase. Three splice variant isoforms have been described. Isoform 1 and isoform 2 appear to be the only activators of gene transcription. Isoform 3, found in rat, does not seem to exist in human. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 12p13. Cellular Component: nucleoplasm; cytoplasm. Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; protein kinase binding; transcription factor activity. Biological Process: regulation of Ras protein signal transduction; transcription from RNA polymerase II promoter; regulation of cell cycle; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; DNA repair; negative regulation of stress-activated MAPK cascade; cell cycle; liver development; regulation of cell proliferation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; regulation of cell growth; G2/M transition of mitotic cell cycle; vasculogenesis; negative regulation of transcription, DNA-dependent

0.1 mg

345 USD