antibody

Mouse monoclonal antibody Anti-Human ATF3

MBS120339

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

44C3a

Antibody

Mouse monoclonal antibody Anti-Human ATF3

ATF3

Homo sapiens activating transcription factor 3

Cyclic AMP-dependent transcription factor ATF-3; cyclic AMP-dependent transcription factor ATF-3; activating transcription factor 3; Activating transcription factor 3

ATF3

ATF3; ATF3

ATF3_HUMAN

Monoclonal

IgG1

44C3a

Mouse

Human

124

100 ug/ml (1.0 ml)

Dot Blot (DB), Immunocytochemistry (ICC)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes. [NCBI Entrez Gene Summary]

95102480

NP_004015.4

NM_004024

14,314 Da

ATF-2 Transcription Factor Network Pathway (138006); ATF4 Activates Genes Pathway (530772); Direct P53 Effectors Pathway (137939); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Hypertrophy Model Pathway (198828); Id Signaling Pathway (198871); Metabolism Of Proteins Pathway (106230); Myometrial Relaxation And Contraction Pathways (198759); PERK Regulates Gene Expression Pathway (105907)

This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]

ATF-3: This protein binds the cAMP response element (CRE) (consensus: 5 -GTGACGT[AC][AG]-3 ), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters. Belongs to the bZIP family. ATF subfamily. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor. Chromosomal Location of Human Ortholog: 1q32.3. Cellular Component: nucleoplasm; nucleolus; nucleus. Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; transcription factor activity; transcription corepressor activity. Biological Process: cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; transcription, DNA-dependent; unfolded protein response; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; gluconeogenesis

0.1 mg

345 USD