Mouse monoclonal antibody Anti-Human NR4A2 | MyBioSource MBS120305 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody Anti-Human NR4A2

catalog :

MBS120305

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

447C2a

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS120305

products type :

Antibody

products full name :

Mouse monoclonal antibody Anti-Human NR4A2

products short name :

NR4A2

products name syn :

Homo sapiens nuclear receptor subfamily 4, group A, member 2; NOT; RNR1; HZF-3; NURR1; TINUR

other names :

Homo sapiens nuclear receptor subfamily 4, group A, member 2 (NR4A2), mRNA; Nuclear receptor subfamily 4 group A member 2; nuclear receptor subfamily 4 group A member 2; NGFI-B/nur77 beta-type transcription factor homolog; T-cell nuclear receptor NOT; immediate-early response protein NOT; intermediate-early receptor protein; nuclear receptor related 1; nur related protein-1, human homolog of; orphan nuclear receptor NR4A2; orphan nuclear receptor NURR1; transcriptionally inducible nuclear receptor related 1; transcriptionally-inducible nuclear receptor; nuclear receptor subfamily 4, group A, member 2; Immediate-early response protein NOT; Orphan nuclear receptor NURR1; Transcriptionally-inducible nuclear receptor

products gene name :

NR4A2

other gene names :

NR4A2; NR4A2; NOT; RNR1; HZF-3; NURR1; TINUR

uniprot entry name :

NR4A2_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

447C2a

host :

Mouse

reactivity :

Human

sequence length :

3546

concentration :

100 ug/ml (1.0 ml)

tested application :

Dot Blot (DB), Western Blot (WB)

other info1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

other info2 :

Sterility: Filtered through a 0.22 um membrane.

products description :

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined. [NCBI Entrez Gene Summary]

ncbi gi num :

187423888

ncbi acc num :

NP_006177.1

ncbi gb acc num :

NM_006186

ncbi mol weight :

59,809 Da

ncbi pathways :

Corticotropin-releasing Hormone Pathway (920957); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Nuclear Receptor Transcription Pathway (105979); Nuclear Receptors Pathway (198848)

ncbi summary :

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

uniprot summary :

NR4A2: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Belongs to the nuclear hormone receptor family. NR4 subfamily. Protein type: Nuclear receptor; DNA-binding. Chromosomal Location of Human Ortholog: 2q22-q23. Cellular Component: nucleoplasm; cytoplasm; nucleus. Molecular Function: ligand-dependent nuclear receptor activity; protein binding; zinc ion binding; protein heterodimerization activity; steroid hormone receptor activity. Biological Process: positive regulation of catalytic activity; adult locomotory behavior; neuron migration; dopamine biosynthetic process; response to insecticide; signal transduction; neuron maturation; post-embryonic development; regulation of respiratory gaseous exchange; general adaptation syndrome; negative regulation of neuron apoptosis; transcription initiation from RNA polymerase II promoter; response to inorganic substance; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; death; regulation of dopamine metabolic process; response to amphetamine; central nervous system projection neuron axonogenesis; habenula development; cellular response to extracellular stimulus; response to hypoxia; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; gene expression. Disease: Parkinson Disease, Late-onset

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage