antibody

Mouse monoclonal antibody Anti-Human MAX

MBS120288

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

73C5a

western blot, dot blot

Antibody

Mouse monoclonal antibody Anti-Human MAX

MAX

Human helix-loop-helix zipper protein (max)

Human helix-loop-helix zipper protein (max) mRNA, complete cds; protein max; class D basic helix-loop-helix protein 4; MYC associated factor X

MAX

MAX; bHLHd4

Monoclonal

IgG2b

73C5a

Mouse

Human

537

100 ug/ml (1.0 ml)

Dot Blot (DB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature for some of them is unknown. [NCBI Entrez Gene Summary]

187390

AAA36200.1

M64240

C-MYC Pathway (169344); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Cyclin A:Cdk2-associated Events At S Phase Entry Pathway (105783); Cyclin E Associated Events During G1/S Transition Pathway (105770); G1/S Transition Pathway (105769); Integrated Breast Cancer Pathway (219801); MAPK Signaling Pathway (198779); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456)

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

MAX: a transcription factor. Forms a DNA- binding protein complex with MYC or MAD. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. CPG methylation of the recognition site greatly inhibits DNA binding, suggesting that DNA methylation may regulate the MYC/MAX complex in vivo. May repress transcription via the recruitment of a chromatin remodeling complex containing H3-K9 histone methyltransferase activity. Three alternatively spliced isoforms have been reported. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 14q23. Cellular Component: nucleoplasm; PML body; cytoplasm; dendrite; nucleus. Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; sequence-specific DNA binding; transcription coactivator activity; transcription cofactor activity; protein complex binding; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; neuron apoptosis; regulation of transcription, DNA-dependent; retina development in camera-type eye; protein complex assembly; response to axon injury; cellular response to starvation; response to insulin stimulus

0.1 mg

345 USD