Mouse monoclonal antibody Anti-Human ID2 | MyBioSource MBS120287 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody Anti-Human ID2

catalog :

MBS120287

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2457C5a

reactivity :

human

application :

immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS120287

products type :

Antibody

products full name :

Mouse monoclonal antibody Anti-Human ID2

products short name :

ID2

products name syn :

Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2); GIG8; ID2A; ID2H; MGC26389

other names :

Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2), mRNA; DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID2; cell growth-inhibiting gene 8; class B basic helix-loop-helix protein 26; helix-loop-helix protein ID2; inhibitor of differentiation 2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; Class B basic helix-loop-helix protein 26; bHLHb26; Inhibitor of DNA binding 2; Inhibitor of differentiation 2

products gene name :

ID2

other gene names :

ID2; ID2; GIG8; ID2A; ID2H; bHLHb26

uniprot entry name :

ID2_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

2457C5a

host :

Mouse

reactivity :

Human

sequence length :

1402

concentration :

100 ug/ml (1.0 ml)

tested application :

Dot Blot (DB), Immunocytochemistry (ICC)

other info1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

other info2 :

Sterility: Filtered through a 0.22 um membrane.

products description :

The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene has been identified for this gene. [NCBI Entrez Gene Summary]

ncbi gi num :

33946335

ncbi acc num :

NP_002157.2

ncbi gb acc num :

NM_002166

ncbi mol weight :

14,917 Da

ncbi pathways :

HIF-1-alpha Transcription Factor Network Pathway (138045); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Id Signaling Pathway (198871); Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway (169352); Signaling Pathways Regulating Pluripotency Of Stem Cells (1026136); Signaling Pathways Regulating Pluripotency Of Stem Cells (1033502); TGF-beta Signaling Pathway (83064); TGF-beta Signaling Pathway (475); Transcriptional Misregulation In Cancer Pathway (523016)

ncbi summary :

The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

uniprot summary :

ID2: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression. Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5. Interacts with NR0B2. Highly expressed in early fetal tissues, including those of the central nervous system. Protein type: Transcription, coactivator/corepressor; DNA-binding. Chromosomal Location of Human Ortholog: 2p25. Cellular Component: nucleoplasm; microtubule cytoskeleton; centrosome; protein complex; cytoplasm; nucleus; chromatin; cytosol. Molecular Function: protein dimerization activity; protein binding. Biological Process: regulation of lipid metabolic process; positive regulation of transcription, DNA-dependent; multicellular organismal development; positive regulation of smooth muscle cell proliferation; cell maturation; negative regulation of transcription from RNA polymerase II promoter; entrainment of circadian clock by photoperiod; locomotor rhythm; natural killer cell differentiation; embryonic digestive tract morphogenesis; negative regulation of osteoblast differentiation; circadian regulation of gene expression; positive regulation of macrophage differentiation; oligodendrocyte development; positive regulation of astrocyte differentiation; negative regulation of B cell differentiation; Peyer s patch development; transcription, DNA-dependent; positive regulation of erythrocyte differentiation; olfactory bulb development; negative regulation of transcription factor activity; neuron fate commitment; mammary gland epithelial cell proliferation; enucleate erythrocyte differentiation; regulation of circadian rhythm; negative regulation of DNA binding; negative regulation of oligodendrocyte differentiation; negative regulation of neuron differentiation; positive regulation of fat cell differentiation; negative regulation of transcription, DNA-dependent; metanephros development; positive regulation of blood pressure

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage