antibody

Mouse monoclonal antibody Anti-Human PPP1R13L

MBS120284

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

2808C5a

western blot, immunocytochemistry

Antibody

Mouse monoclonal antibody Anti-Human PPP1R13L

PPP1R13L

Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 13 like (PPP1R13L); RAI; IASPP; NKIP1; iASPP gene

Homo sapiens protein phosphatase 1, regulatory subunit 13 like (PPP1R13L), transcript variant 2, mRNA; RelA-associated inhibitor; relA-associated inhibitor; NFkB interacting protein 1; NFkB-interacting protein 1; PPP1R13B-like protein; inhibitor of ASPP protein; inhibitor of apoptosis stimulating protein of p53; protein iASPP; protein phosphatase 1, regulatory (inhibitor) subunit 13 like; retinoic acid induced 4; protein phosphatase 1, regulatory subunit 13 like; Inhibitor of ASPP protein; Protein iASPP; NFkB-interacting protein 1; PPP1R13B-like protein

PPP1R13L

PPP1R13L; PPP1R13L; RAI; RAI4; IASPP; NKIP1

IASPP_HUMAN

Monoclonal

IgG1

2808C5a

Mouse

Human

3120

100 ug/ml (1.0 ml)

Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis{EC1,EC2,EC3,EC4}. [UniProtKB Function]

215820633

NP_006654.2

NM_006663

89,091 Da

Integrated Pancreatic Cancer Pathway (711360); TNF-alpha/NF-kB Signaling Pathway (198884); P53 Pathway (138067)

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

PPP1R13L: an oncoprotein that interacts with and inhibits NF-kappaB, Sp1 and p53. Plays a central role in regulation of apoptosis and transcription. May inhibit p53 by preventing its association with ASPP1 or ASPP2, thereby suppressing the subsequent activation of apoptosis. Required for neuronal survival after axonal injury. Two alternatively spliced isoforms have been described. Isoform 1 is preferrentially found in the cytoplasm; isoform 2 is nuclear. Protein type: Transcription, coactivator/corepressor; Apoptosis; Phosphatase, regulatory subunit. Chromosomal Location of Human Ortholog: 19q13.32. Cellular Component: intercellular bridge; cytoplasm; nucleus; cell junction. Molecular Function: identical protein binding; protein binding; transcription factor binding; transcription corepressor activity. Biological Process: transcription, DNA-dependent; apoptosis; multicellular organism growth; negative regulation of transcription from RNA polymerase II promoter; multicellular organismal homeostasis; embryonic camera-type eye development; cardiac muscle contraction; post-embryonic development; hair cycle

0.1 mg

345 USD