antibody

Mouse monoclonal antibody Anti-Human FBXL4

MBS120280

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

2352C1a

western blot, dot blot

Antibody

Mouse monoclonal antibody Anti-Human FBXL4

FBXL4

Homo sapiens F-box and leucine-rich repeat protein 4 (FBXL4); FBL4; FBL5

Homo sapiens F-box and leucine-rich repeat protein 4 (FBXL4), transcript variant 1, mRNA; F-box/LRR-repeat protein 4; F-box/LRR-repeat protein 4; F-box and leucine-rich repeat protein 4; F-box and leucine-rich repeat protein 4; F-box protein FBL4/FBL5

FBXL4

FBXL4; FBXL4; FBL4; FBL5; MTDPS13

FBXL4_HUMAN

Monoclonal

IgG1

2352C1a

Mouse

Human

2810

100 ug/ml (1.0 ml)

Dot Blot (DB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least 9 tandem leucine-rich repeats. [NCBI Entrez Gene Summary]

524584785

NP_036292.2

NM_012160

70,097 Da

This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

FBXL4: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Chromosomal Location of Human Ortholog: 6q16.1-q16.3. Cellular Component: nucleoplasm; mitochondrial intermembrane space; ubiquitin ligase complex. Biological Process: ubiquitin-dependent protein catabolic process. Disease: Mitochondrial Dna Depletion Syndrome 13 (encephalomyopathic Type)

0.1 mg

345 USD