product summary
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company name :
MyBioSource
product type :
antibody
product name :
Mouse monoclonal antibody Anti-Human CLNS1A
catalog :
MBS120273
quantity :
0.1 mg
price :
345 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2187C2a
reactivity :
human
application :
western blot, immunocytochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS120273
products type :
Antibody
products full name :
Mouse monoclonal antibody Anti-Human CLNS1A
products short name :
CLNS1A
products name syn :
Homo sapiens chloride channel, nucleotide-sensitive, 1A (CLNS1A); CLCI; ICln; CLNS1B
other names :
Homo sapiens chloride channel, nucleotide-sensitive, 1A (CLNS1A), mRNA; Methylosome subunit pICln; methylosome subunit pICln; chloride channel regulatory protein; chloride channel, nucleotide sensitive 1A; chloride conductance regulatory protein ICln; chloride ion current inducer protein; i(Cln); reticulocyte pICln; reticulocyte protein ICln; chloride channel, nucleotide-sensitive, 1A; Chloride channel, nucleotide sensitive 1A; Chloride conductance regulatory protein ICln; I(Cln); Chloride ion current inducer protein; ClCI; Reticulocyte pICln
products gene name :
CLNS1A
other gene names :
CLNS1A; CLNS1A; CLCI; ICln; CLNS1B
uniprot entry name :
ICLN_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
2187C2a
host :
Mouse
reactivity :
Human
sequence length :
1378
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. [UniProtKB Function]
ncbi gi num :
222418789
ncbi acc num :
NP_001284.1
ncbi gb acc num :
NM_001293
ncbi mol weight :
26,215 Da
ncbi pathways :
Gene Expression Pathway (105937); Metabolism Of Non-coding RNA Pathway (106228); RNA Transport Pathway (177876); RNA Transport Pathway (175229); SnRNP Assembly Pathway (106229)
ncbi summary :
This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. [provided by RefSeq, Feb 2009]
uniprot summary :
ICLN: The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. Belongs to the pICln (TC 1.A.47) family. Protein type: Channel, chloride. Chromosomal Location of Human Ortholog: 11q13.5-q14. Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; plasma membrane; nucleus; cytosol. Molecular Function: protein binding. Biological Process: spliceosomal snRNP biogenesis; chloride transport; gene expression; cell volume homeostasis
size1 :
0.1 mg
price1 :
345 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

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