catalog number :
MBS120272
products full name :
Mouse monoclonal antibody Anti-Human LSM10
products short name :
LSM10
products name syn :
Homo sapiens LSM10, U7 small nuclear RNA associated (LSM10); MST074; MSTP074; MGC15749
other names :
Homo sapiens LSM10, U7 small nuclear RNA associated (LSM10), mRNA; U7 snRNA-associated Sm-like protein LSm10; U7 snRNA-associated Sm-like protein LSm10; U7 snRNP-specific Sm-like protein LSM10; LSM10, U7 small nuclear RNA associated
products gene name :
LSM10
other gene names :
LSM10; LSM10; MST074; MSTP074
uniprot entry name :
LSM10_HUMAN
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB), Immunocytochemistry (ICC)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
Binds specifically to U7 snRNA. [UniProtKB Function]
ncbi acc num :
NP_116270.1
ncbi gb acc num :
NM_032881
ncbi mol weight :
14,080 Da
ncbi pathways :
Cleavage Of Growing Transcript In The Termination Region Pathway (106560); Gene Expression Pathway (105937); Processing Of Capped Intronless Pre-mRNA Pathway (160951); RNA Polymerase II Transcription Pathway (106557); RNA Polymerase II Transcription Termination Pathway (106559); SLBP Dependent Processing Of Replication-Dependent Histone Pre-mRNAs Pathway (160952); SLBP Independent Processing Of Histone Pre-mRNAs Pathway (160953)
uniprot summary :
LSM10: Appears to function in the U7 snRNP complex that is involved in histone 3 -end processing. Increases U7 snRNA levels but not histone 3 -end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. Belongs to the snRNP Sm proteins family. Chromosomal Location of Human Ortholog: 1p34.3. Cellular Component: nucleoplasm; Cajal body; nucleus. Molecular Function: protein binding. Biological Process: transcription from RNA polymerase II promoter; RNA splicing; histone mRNA metabolic process; gene expression; mRNA 3 -end processing; termination of RNA polymerase II transcription