product summary
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company name :
MyBioSource
product type :
antibody
product name :
Mouse monoclonal antibody Anti-Human KNTC2
catalog :
MBS120269
quantity :
0.1 mg
price :
345 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2497C3a
reactivity :
human
application :
western blot, immunocytochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS120269
products type :
Antibody
products full name :
Mouse monoclonal antibody Anti-Human KNTC2
products short name :
KNTC2
products name syn :
Homo sapiens NDC80 homolog, kinetochore complex component (S.cerevisiae) (NDC80); NDC80; HEC; HEC1; TID3; hsNDC80
other names :
Homo sapiens NDC80 kinetochore complex component (NDC80), mRNA; Kinetochore protein NDC80 homolog; kinetochore protein NDC80 homolog; NDC80 homolog, kinetochore complex component; NDC80 kinetochore complex component homolog; highly expressed in cancer protein; highly expressed in cancer, rich in leucine heptad repeats; kinetochore associated 2; kinetochore protein Hec1; kinetochore-associated protein 2; retinoblastoma-associated protein HEC; NDC80 kinetochore complex component; Highly expressed in cancer protein; Kinetochore protein Hec1; HsHec1; Kinetochore-associated protein 2; Retinoblastoma-associated protein HEC
products gene name :
KNTC2
other gene names :
NDC80; NDC80; HEC; HEC1; TID3; KNTC2; HsHec1; hsNDC80
uniprot entry name :
NDC80_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
2497C3a
host :
Mouse
reactivity :
Human
sequence length :
2209
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.[supplied by OMIM] [NCBI Entrez Gene Summary]
ncbi gi num :
215820615
ncbi acc num :
NP_006092.1
ncbi gb acc num :
NM_006101
ncbi mol weight :
73,913 Da
ncbi pathways :
Aurora B Signaling Pathway (138080); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); M Phase Pathway (105812); Mitotic Anaphase Pathway (105818); Mitotic Metaphase And Anaphase Pathway (730317); Mitotic Prometaphase Pathway (105815); PLK1 Signaling Events Pathway (138007); Resolution Of Sister Chromatid Cohesion Pathway (730315); Separation Of Sister Chromatids Pathway (730318)
ncbi summary :
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]
uniprot summary :
HEC1: plays an essential role in chromosome segregation by interacting through its coiled-coil domains with several proteins that modulate the G2/M phase. Phosphorylation by Nek2 is essential for faithful chromosome segregation. Required for the recruitment of Mps1 kinase and Mad1/Mad2 complexes to kinetochores. Protein type: Cell cycle regulation. Chromosomal Location of Human Ortholog: 18p11.32. Cellular Component: kinetochore; membrane; cytosol; nucleus; chromosome, pericentric region. Molecular Function: protein binding; structural constituent of cytoskeleton. Biological Process: mitosis; mitotic spindle organization and biogenesis; attachment of spindle microtubules to kinetochore during mitosis; mitotic sister chromatid segregation; establishment of mitotic spindle orientation; cell division; mitotic cell cycle; attachment of spindle microtubules to kinetochore; chromosome segregation
size1 :
0.1 mg
price1 :
345 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

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