Mouse monoclonal antibody Anti-Human DHX9 | MyBioSource MBS120267 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody Anti-Human DHX9

catalog :

MBS120267

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2274D5a

reactivity :

human

application :

western blot, dot blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS120267

products type :

Antibody

products full name :

Mouse monoclonal antibody Anti-Human DHX9

products short name :

DHX9

products name syn :

Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 9 (DHX9), transcript variant 1; LKP; RHA; DDX9; NDHII; NDH II

other names :

Homo sapiens DEAH (Asp-Glu-Ala-His) box helicase 9 (DHX9), transcript variant 1, mRNA; ATP-dependent RNA helicase A; ATP-dependent RNA helicase A; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9; DEAH (Asp-Glu-Ala-His) box polypeptide 9; DEAH box protein 9; leukophysin; nuclear DNA helicase II; DEAH (Asp-Glu-Ala-His) box helicase 9; DEAH box protein 9; Leukophysin; LKP; Nuclear DNA helicase II; NDH II

products gene name :

DHX9

other gene names :

DHX9; DHX9; LKP; RHA; DDX9; NDH2; NDHII

uniprot entry name :

DHX9_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

2274D5a

host :

Mouse

reactivity :

Human

sequence length :

4543

concentration :

100 ug/ml (1.0 ml)

tested application :

Dot Blot (DB)

other info1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

other info2 :

Sterility: Filtered through a 0.22 um membrane.

products description :

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein with RNA helicase activity. It may participate in melting of DNA:RNA hybrids, such as those that occur during transcription, and may play a role in X-linked gene expression. It contains 2 copies of a double-stranded RNA-binding domain, a DEXH core domain and an RGG box. The RNA-binding domains and RGG box influence and regulate RNA helicase activity. [NCBI Entrez Gene Summary]

ncbi gi num :

289063428

ncbi acc num :

NP_001348.2

ncbi gb acc num :

NM_001357

ncbi mol weight :

24,336 Da

ncbi pathways :

Activated TLR4 Signalling Pathway (106400); Cytosolic Sensors Of Pathogen-associated DNA Pathway (576255); DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway (833822); Gene Expression Pathway (105937); Immune System Pathway (106386); Innate Immune System Pathway (106387); MyD88 Cascade Initiated On Plasma Membrane Pathway (205107); MyD88 Dependent Cascade Initiated On Endosome Pathway (187081); MyD88-independent Cascade Pathway (106401); MyD88:Mal Cascade Initiated On Plasma Membrane Pathway (106390)

ncbi summary :

This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010]

uniprot summary :

DDX9: a helicase that unwinds double-stranded DNA and RNA in a 3 to 5 direction. Interacts with the RNA-induced silencing complex (RISC) in human cells and functions in RISC loading. Generates multiple secondary structures that influence RNA-binding proteins. Has a dsRNA binding motif at the N-terminus, RGG-box at the carboxyl terminus, and a bidirectional nuclear transport domain of 110 amino acids at the carboxyl terminus. May play a role in X-linked gene expression. Protein type: Nucleolus; RNA processing; RNA splicing; Nuclear receptor co-regulator; EC 3.6.4.13; RNA-binding; Helicase; Spliceosome. Chromosomal Location of Human Ortholog: 1q25. Cellular Component: nucleoplasm; centrosome; membrane; cytoplasm; nucleolus; cytosol; nucleus; ribonucleoprotein complex. Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; ATP binding; RNA helicase activity; ATP-dependent RNA helicase activity. Biological Process: circadian rhythm; osteoblast differentiation; nuclear mRNA splicing, via spliceosome; RNA processing; RNA splicing; positive regulation of interferon type I production; innate immune response; gene expression; DNA duplex unwinding

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage