antibody

Mouse monoclonal antibody Anti-Human FALZ

MBS120266

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

2343C3a

western blot, dot blot

Antibody

Mouse monoclonal antibody Anti-Human FALZ

FALZ

Homo sapiens bromodomain PHD finger transcription factor (BPTF),transcript variant 1; BPTF;FAC1; NURF301

Homo sapiens bromodomain PHD finger transcription factor (BPTF), transcript variant 1, mRNA; Nucleosome-remodeling factor subunit BPTF; nucleosome-remodeling factor subunit BPTF; bromodomain and PHD domain transcription factor; bromodomain and PHD finger-containing transcription factor; fetal Alz-50 clone 1 protein; fetal Alz-50 reactive clone 1; fetal Alzheimer antigen; nucleosome remodeling factor, large subunit; bromodomain PHD finger transcription factor; Bromodomain and PHD finger-containing transcription factor; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen

FALZ

BPTF; BPTF; FAC1; FALZ; NURF301

BPTF_HUMAN

Monoclonal

IgG1

2343C3a

Mouse

Human

10914

100 ug/ml (1.0 ml)

Dot Blot (DB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [NCBI Entrez Gene Summary]

119395731

NP_872579.2

NM_182641

322,217 Da

This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]

FALZ: Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on Lys-4 (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. Belongs to the PBTF family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 17q24.3. Cellular Component: nucleoplasm; cytoplasm; nucleus. Molecular Function: DNA-dependent ATPase activity; protein binding; zinc ion binding; sequence-specific DNA binding; transcription factor binding. Biological Process: chromatin remodeling; anterior/posterior pattern formation; embryonic placenta development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; brain development; endoderm development

0.1 mg

345 USD