antibody

Mouse monoclonal antibody Anti-Human KPNA4

MBS120254

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

2500D3a

western blot, immunocytochemistry

Antibody

Mouse monoclonal antibody Anti-Human KPNA4

KPNA4

Homo sapiens karyopherin alpha 4 (importin alpha 3) (KPNA4); QIP1; SRP3; IPOA3; MGC12217; MGC26703

Homo sapiens karyopherin alpha 4 (importin alpha 3) (KPNA4), mRNA; Importin subunit alpha-3; importin subunit alpha-3; importin alpha Q1; importin subunit alpha-4; karyopherin subunit alpha-4; karyopherin alpha 4 (importin alpha 3); Importin alpha Q1; Qip1; Karyopherin subunit alpha-4

KPNA4

KPNA4; KPNA4; QIP1; SRP3; IPOA3

IMA3_HUMAN

Monoclonal

IgG2a

2500D3a

Mouse

Human

8981

100 ug/ml (1.0 ml)

Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [NCBI Entrez Gene Summary]

339275982

NP_002259.1

NM_002268

57,887 Da

Antiviral Mechanism By IFN-stimulated Genes Pathway (530760); Cytokine Signaling In Immune System Pathway (366171); ISG15 Antiviral Mechanism Pathway (530761); Immune System Pathway (106386); Interferon Signaling Pathway (187103); Leptin Signaling Pathway (672456)

The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]

KPNA4: an alpha importin protein that functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Forms a complex with importin beta-1 subunit. Protein type: Adaptor/scaffold; Chaperone; Nuclear import; Karyopherin. Chromosomal Location of Human Ortholog: 3q25.33. Cellular Component: nucleoplasm; cytosol. Molecular Function: protein binding; protein transporter activity. Biological Process: response to hydrogen peroxide; cytokine and chemokine mediated signaling pathway; NLS-bearing substrate import into nucleus

0.1 mg

345 USD