antibody

Mouse monoclonal antibody Anti-Human EXOSC2

MBS120252

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

2334C3a

western blot, dot blot

Antibody

Mouse monoclonal antibody Anti-Human EXOSC2

EXOSC2

Homo sapiens exosome component 2 (EXOSC2), mRNA; p7; RRP4; Rrp4p;hRrp4p

Homo sapiens exosome component 2 (EXOSC2), transcript variant 1, mRNA; Exosome complex component RRP4; exosome complex component RRP4; exosome complex exonuclease RRP4; homolog of yeast RRP4 (ribosomal RNA processing 4), 3' 5' exoribonuclease (RRP4); homolog of yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease; ribosomal RNA-processing protein 4; exosome component 2; Exosome component 2; Ribosomal RNA-processing protein 4

EXOSC2

EXOSC2; EXOSC2; p7; RRP4; Rrp4p; hRrp4p

EXOS2_HUMAN

Monoclonal

IgG1

2334C3a

Mouse

Human

2034

100 ug/ml (1.0 ml)

Dot Blot (DB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

Component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions. Required for the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA. Has a 3'-5' exonuclease activity. [UniProtKB Function]

544186083

NP_055100.2

NM_014285

30,045 Da

ATF4 Activates Genes Pathway (530772); Butyrate Response Factor 1 (BRF1) Destabilizes MRNA Pathway (187213); Deadenylation-dependent MRNA Decay Pathway (160993); Exosome, Archaea Pathway (413456); Exosome, Archaea Pathway (468396); Exosome, Eukaryotes Pathway (413457); Exosome, Eukaryotes Pathway (468397); Gene Expression Pathway (105937); KSRP Destabilizes MRNA Pathway (187215); Metabolism Of Proteins Pathway (106230)

RRP4: Non-catalytic component of the RNA exosome complex which has 3 5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7. Protein type: EC 3.1.13.-; Nucleolus; RNA processing; Ribonuclease. Chromosomal Location of Human Ortholog: 9q34. Cellular Component: cytoplasm; nucleolus; exosome (RNase complex); cytosol; nucleus; nuclear exosome (RNase complex). Molecular Function: protein binding; 3 -5 -exoribonuclease activity; exoribonuclease activity; 7S RNA binding. Biological Process: gene expression; exonucleolytic trimming to generate mature 3 -end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); positive regulation of cell growth; rRNA processing; mRNA catabolic process, deadenylation-dependent decay

0.1 mg

345 USD