antibody

Mouse monoclonal antibody Anti-Human SMAD1

MBS120248

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

913C1b

western blot, immunocytochemistry, immunoprecipitation, flow cytometry, FACS

Antibody

Mouse monoclonal antibody Anti-Human SMAD1

SMAD1

Homo sapiens SMAD family member 1 (SMAD1), transcript variant 1; BSP1; JV41; JV4-1;MADH1; MADR1

Homo sapiens SMAD family member 1 (SMAD1), transcript variant 1, mRNA; Mothers against decapentaplegic homolog 1; mothers against decapentaplegic homolog 1; MAD homolog 1; MAD, mothers against decapentaplegic homolog 1; Mad-related protein 1; SMAD, mothers against DPP homolog 1; TGF-beta signaling protein 1; transforming growth factor-beta signaling protein 1; transforming growth factor-beta-signaling protein 1; SMAD family member 1; JV4-1; Mad-related protein 1; SMAD family member 1; SMAD 1; Smad1; hSMAD1; Transforming growth factor-beta-signaling protein 1; BSP-1

SMAD1

SMAD1; SMAD1; BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1

SMAD1_HUMAN

Monoclonal

IgG1

913C1b

Mouse

Human

3056

100 ug/ml (1.0 ml)

Dot Blot (DB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FC/FACS)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [NCBI Entrez Gene Summary]

51173725

NP_005891.1

NM_005900

15,406 Da

ALK1 Signaling Events Pathway (137968); ALK2 Signaling Events Pathway (137983); Angiogenesis Pathway (198772); BMP Receptor Signaling Pathway (137948); BMP Signaling Pathway (1084755); BMP Signaling Pathway (1108218); BMP Signalling And Regulation Pathway (198910); Delta-Notch Signaling Pathway (198879); ErbB1 Downstream Signaling Pathway (138057); Heart Development Pathway (198802)

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

SMAD1: transcription factor phosphorylated and activated by bone morphogenetic protein type 1 receptor kinases. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Phosphorylated forms dimerize with collaborating Smad4 and are translocated into the nucleus, where the transcription of target genes is stimulated. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 4q31. Cellular Component: nucleoplasm; transcription factor complex; protein complex; cytoplasm; integral to membrane; nuclear inner membrane; intracellular; nucleus; cytosol. Molecular Function: identical protein binding; protein binding; metal ion binding; receptor signaling protein activity; transcription factor activity; protein kinase binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity. Biological Process: wound healing; cardiac muscle cell proliferation; primary microRNA processing; embryonic pattern specification; signal transduction; protein amino acid phosphorylation; mesodermal cell fate commitment; BMP signaling pathway; negative regulation of cell proliferation; homeostatic process; ureteric bud development; transforming growth factor beta receptor signaling pathway; midbrain development; inflammatory response; hindbrain development; response to drug; transcription, DNA-dependent; MAPKKK cascade; positive regulation of dendrite morphogenesis; response to organic nitrogen; SMAD protein complex assembly; positive regulation of osteoblast differentiation; cartilage development; gamete generation; positive regulation of transcription from RNA polymerase II promoter; osteoblast fate commitment

0.1 mg

345 USD