product summary
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company name :
MyBioSource
product type :
antibody
product name :
Mouse monoclonal antibody Anti-Human RHOB
catalog :
MBS120245
quantity :
0.1 mg
price :
345 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2916C2a
reactivity :
human
application :
western blot, dot blot
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS120245
products type :
Antibody
products full name :
Mouse monoclonal antibody Anti-Human RHOB
products short name :
RHOB
products name syn :
Homo sapiens ras homolog gene family, member B (RHOB); ARH6;ARHB; RHOH6; MST081; MSTP081
other names :
Homo sapiens ras homolog family member B (RHOB), mRNA; rho-related GTP-binding protein RhoB; Aplysia RAS-related homolog 6; h6; oncogene RHO H6; ras homolog gene family, member B; rho cDNA clone 6; ras homolog family member B
products gene name :
RHOB
other gene names :
RHOB; RHOB; ARH6; ARHB; RHOH6; MST081; MSTP081
uniprot entry name :
RHOB_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
2916C2a
host :
Mouse
reactivity :
Human
sequence length :
2387
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. [UniProtKB Function]
ncbi gi num :
748585188
ncbi acc num :
NP_004031.1
ncbi gb acc num :
NM_004040
ncbi mol weight :
22,123 Da
ncbi pathways :
Androgen Receptor Signaling Pathway (198806); Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); Focal Adhesion Pathway (198795); G Alpha (12/13) Signalling Events Pathway (106041); GPCR Downstream Signaling Pathway (119548); GPVI-mediated Activation Cascade Pathway (106036); Hemostasis Pathway (106028); Neural Crest Differentiation Pathway (672460); Platelet Activation, Signaling And Aggregation Pathway (106034)
uniprot summary :
RHOB: a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Protein type: G protein, monomeric, Rho; Tumor suppressor; G protein, monomeric; Motility/polarity/chemotaxis; G protein. Chromosomal Location of Human Ortholog: 2p24. Cellular Component: focal adhesion; late endosome membrane; early endosome; plasma membrane; endosome membrane; nucleus; cytosol; cleavage furrow. Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding. Biological Process: platelet activation; axon guidance; transformed cell apoptosis; apoptosis; positive regulation of apoptosis; metabolic process; cytokinesis; Rho protein signal transduction; negative regulation of cell cycle; intracellular protein transport; regulation of small GTPase mediated signal transduction; positive regulation of angiogenesis; small GTPase mediated signal transduction; endosome to lysosome transport; angiogenesis; cell adhesion; blood coagulation
size1 :
0.1 mg
price1 :
345 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

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