catalog number :
MBS120232
products full name :
Mouse monoclonal antibody Anti-Human TPX2
products short name :
TPX2
products name syn :
Homo sapiens TPX2, microtubule-associated, homolog (Xenopus laevis) (TPX2); DIL2; p100; DIL-2; HCTP4; FLS353;HCA519; REPP86; C20orf1; C20orf2; GD:C20orf1
other names :
Homo sapiens TPX2, microtubule-associated (TPX2), mRNA; Targeting protein for Xklp2; targeting protein for Xklp2; TPX2, microtubule-associated protein homolog; TPX2, microtubule-associated, homolog; differentially expressed in cancerous and non-cancerous lung cells 2; differentially expressed in lung cells; hepatocellular carcinoma-associated antigen 519; hepatocellular carcinoma-associated antigen 90; preferentially expressed in colorectal cancer; protein fls353; restricted expression proliferation associated protein 100; restricted expression proliferation-associated protein 100; TPX2, microtubule-associated; Differentially expressed in cancerous and non-cancerous lung cells 2; DIL-2; Hepatocellular carcinoma-associated antigen 519; Hepatocellular carcinoma-associated antigen 90; Protein fls353; Restricted expression proliferation-associated protein 100; p100
products gene name :
TPX2
other gene names :
TPX2; TPX2; DIL2; p100; DIL-2; HCTP4; FLS353; HCA519; REPP86; C20orf1; C20orf2; GD:C20orf1
uniprot entry name :
TPX2_HUMAN
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FC/FACS)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
ncbi acc num :
NP_036244.2
ncbi gb acc num :
NM_012112
ncbi mol weight :
89,393 Da
ncbi pathways :
Aurora A Signaling Pathway (137925); Gastric Cancer Network 1 Pathway (760635); PLK1 Signaling Events Pathway (138007)
uniprot summary :
TPX2: a microtubule-associated protein required for meiotic and mitotic spindle assembly. Targets a plus end-directed motor (XKLP2) to the minus ends of microtubules in the mitotic spindle. Required for microtubule nucleation around chromosomes in response to the local generation of RanGTP. Binds to and activates Aurora A kinase and targets it to the mitotic spindle. Protein type: Microtubule-binding; Cell cycle regulation. Chromosomal Location of Human Ortholog: 20q11.2. Cellular Component: axon hillock; nucleoplasm; microtubule cytoskeleton; spindle pole; microtubule; cytoplasm; spindle; nucleus. Molecular Function: protein binding; GTP binding; protein kinase binding; ATP binding. Biological Process: cell proliferation; mitosis; apoptosis; cell division; activation of protein kinase activity